Results 221 to 230 of about 1,869,252 (339)

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Patient Satisfaction With Medication Pricing in Community Pharmacy Settings: A Cross‐Sectional Study of Individuals With Comorbidities

AGING MEDICINE, EarlyView.
The majority of patients in Malaysia purchase medications at community pharmacies for simple medical conditions. One‐fourth of them are not satisfied with the pricing practices at these pharmacies. The majority rely on medical insurance to purchase routine medications.
Amelia Ravindran, Palanisamy Sivanandy, Sajesh Kalkandi Veettil, Priya Manirajan   +3 more
wiley   +1 more source

Prevalence of potentially inappropriate medication use and its association with hospitalization among older adults with chronic disease in the Amhara region, Ethiopia: a multicenter prospective cohort study. [PDF]

Ther Adv Drug Saf
Tarekegn GY, Dagnew FN, Wondm SA, Moges TA, Asmare ZA, Ayele TM, Anberbr SS, Zeben DH, Zerihun TE, Kassaw AT, Mussie DA, Melese TB, Dagnew SB.   +12 more
europepmc   +1 more source

The Effectiveness of Anti‐Adhesion Barriers on Prevention of Postoperative Adhesive Bowel Obstruction: Disease‐Free Survival Analysis

Annals of Gastroenterological Surgery, EarlyView.
We performed a survival analysis of abdominal gastroenterological cancer surgery cases with and without anti‐adhesive barriers, with the development of adhesive bowel obstruction as the outcome. The incidence of adhesive bowel obstruction was significantly lower in patients undergoing open or laparoscopic colorectal surgery in the anti‐adhesive ...
Shota Ebinuma, Susumu Kunisawa, Daisuke Takada, Kiyohide Fushimi, Akinobu Taketomi, Yuichi Imanaka   +5 more
wiley   +1 more source

Endothelin-1 Is Independently Associated with the Annual Risk of Heart Failure Hospitalization [PDF]

, 2014
Eitan Friedman, David Shisler, John A. Todd, Joel Estis, Adnan Shah, Niamh Nolan, Daniel J. Lenihan   +6 more
openalex   +1 more source

Validation of the Safe Application of Tokyo Guideline 2018 (TG18) Severity Grading and Treatment Algorithm in Super‐Elderly Patients Aged 85 and Over With Acute Cholecystitis: A Study in the Japanese Tertiary Care Hospital

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background With population aging and extended healthy life expectancy, the management of acute cholecystitis (AC) in patients aged ≥ 85 years has evolved. However, the Tokyo Guidelines 2018 (TG18) for AC provide no specific risk assessment criteria for this population.
Yuta Kobayashi, Ryo Oikawa, Yumi Shibuya, Masakazu Tatsuno, Atsuya Kamiyama, Tsuyoshi Ozawa, Keiichiro Hara, Shinogu Hatano, Shojiro Hata, Hirokazu Yamaguchi   +9 more
wiley   +1 more source

Is it Possible To Identify Patients After Their First Hospitalization for a Psychotic Disorder Who Do Not Use Anti-Psychotics and are Not Later Rehospitalized? [PDF]

Schizophr Bull
Krivoy A, Tiihonen J, Nissan J, Dotan A, Arnheim D, Menkes-Caspi N, Taub S, Tuppurainen H, Mittendorfer-Rutz E, Davidson M, Davis JM, Weiser M, Taipale H.   +12 more
europepmc   +1 more source

Gender Differences Among Patients Hospitalized with Acute Heart Failure in a Tertiary Care Teaching Hospital

, 2022
Preema Dsa, Soumya Umesh, Deepak Kamath
openalex   +1 more source

Exercise and Nutrition Prehabilitation Program During Preoperative Chemotherapy Followed by Esophagectomy in Older Patients With Esophageal Cancer: A Randomized Clinical Trial

Annals of Gastroenterological Surgery, EarlyView.
This prospective randomized trial evaluated whether prehabilitation, exercise and nutrition intervention, enhance skeletal muscle mass during neoadjuvant chemotherapy in older patients with esophageal cancer undergoing esophagectomy. We also investigated whether exercise alone was sufficient to increase skeletal muscle mass, and whether nutritional ...
Keijiro Sugimura, Takashi Kanemura, Tomohira Takeoka, Takahito Sugase, Norihiro Matsuura, Kazuyoshi Yamamoto, Masahiko Yano, Hiroshi Miyata   +7 more
wiley   +1 more source

Risk Factors for Anastomotic Stricture and Obstructive Symptoms Following Double‐Flap Technique Reconstruction After Proximal Gastrectomy

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study investigated risk factors for anastomotic stricture and obstructive symptoms following double‐flap technique (DFT) reconstruction after proximal gastrectomy. Mucosal detachment, potentially caused by thermal damage, was identified as a significant risk factor for anastomotic stricture, while continuous suturing at the esophago ...
Shinji Kuroda, Yoshihiko Kakiuchi, Satoru Kikuchi, Hajime Kashima, Nobuhiko Kanaya, Shunya Hanzawa, Kenjiro Kumano, Masahiko Nishizaki, Shunsuke Kagawa, Toshiyoshi Fujiwara   +9 more
wiley   +1 more source