Results 81 to 90 of about 10,103,776 (263)

Association between critical care occupancy and code status decisions during resource scarcity: a retrospective cohort study

BMC Medical Ethics
Background Code status determination typically relies on the expected benefits and harms of treatment intensification and patient values and preferences. Resource availability may also influence code status decisions.
Stijn Bex, Lorna Guinness, Christophe Gaudet-Blavignac, Jeremy H. Martin, Jérôme Stirnemann, Thomas Agoritsas, Anne Rossel, Antonio Leidi, Olivier Grosgurin, Jean-Luc Reny, Christophe A. Fehlmann, Samia Hurst-Majno, Christophe Marti   +12 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Remuneração do trabalho médico: um estudo sobre seus sistemas e formas em hospitais gerais de Belo Horizonte

Cadernos de Saúde Pública
Com o propósito de realizar uma análise descritiva dos sistemas e formas de remuneração do trabalho médico em hospitais gerais de Belo Horizonte e apreender a percepção de gerentes hospitalares, médicos e representantes das associações corporativas ...
Mariangela L. Cherchiglia
doaj  

Training the trainees in robotic surgery – a pilot scheme in the United Kingdom

BMC Medical Education
Background Training in robotic colorectal surgery is predominantly confined to senior trainees and consultants. The lack of robotic training of the general surgical specialist trainee (ST) in the formative stages of training has led to widespread ...
Mohammed Al-Ani, Samuel Massias, Panduka Jayawardena, Esha Khanderia, Joshua Franklyn, Khawar Hashmi, Vanash Patel   +6 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Development of nurses’ core competencies by head nurses in general hospitals, southern Thailand

Journal of Health Science and Medical Research (JHSMR), 2008
Objective: To examine the level of practice employed by head nurses in the development of their nurses' core competencies in both accredited and non-accredited general hospitals in Southern Thailand, and then to compare the two groups.
K Kaseng, N Boonyoung, A Apichato
doaj  

Gallstone ileus: dilemma in the management

Clinics and Practice, 2017
Gallstone ileus is a mechanical intestinal obstruction caused due to impaction of a large gallstone within the bowel. The ideal treatment of gallstone ileus remains controversial, with the main dilemma being between a one-stage and a two-stage surgical ...
Girish D. Bakhshi, Rajesh G. Chincholkar, Jasmine R. Agarwal, Madhukar R. Gupta, Prachiti S. Gokhe, Amogh R. Nadkarni   +5 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source