British Journal of Clinical Pharmacology, EarlyView.Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá +4 more
wiley +1 more source
Predictive modelling of vascular surgery trends using machine learning: a comparative study of Irish public and private tertiary referral centres. [PDF]
Front SurgSultan S +4 more
europepmc +1 more source
Prescribing variation across Europe: Insights into prescribing practices and educational needs
British Journal of Clinical Pharmacology, EarlyView.Aims Prescribing medication is a complex process, influenced by many factors that can be weighed differently. Four prescriber profiles have been identified: pragmatic‐contextual, guideline‐oriented, experience‐driven and vulnerability‐focused. However, the extent to which European prescribers identify with these profiles and the role of these profiles ...
Mariëlle G. Hartjes +3 more
wiley +1 more source
Urban-rural differences in hospital beds and employee income: a study using the rurality index for healthcare research in Japan. [PDF]
J Rural MedMurasawa H, Ogata T, Ito H.
europepmc +1 more source
Low‐intervention clinical trials in Spain: Do they progress?
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Low‐Intervention Clinical Trials (LICTs) are generally pragmatic trials that investigate medicinal products already authorized for use. In 2014, simplified regulatory frameworks were introduced for LICTs with the aim of reducing regulatory burden and operational complexity, to foster non‐commercial clinical trials (NCCTs); the mandatory ...
Claudia Erika Delgado‐Espinoza +4 more
wiley +1 more source
Co-evolution of private and public hospitals: spatiotemporal disparities, geospatial interactions, and social determinants over 19 years in Sichuan, China. [PDF]
Front Public HealthLiu X +9 more
europepmc +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Determining elderly-friendly radiation oncology clinics: a comparative analysis of accessibility and transport, physical environment, and privacy aspects (TROD 013 - 005). [PDF]
BMC GeriatrKirli Bolukbas M +3 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti +9 more
wiley +1 more source
Assessing Surgical Care under the Government‑Funded Health Insurance Scheme-Pradhan Mantri Jan Arogya Yojana in India. [PDF]
Ann Glob HealthIyer H +5 more
europepmc +1 more source