Results 251 to 260 of about 3,648,409 (294)
How senior leaders support innovations in large learning health systems: Insights from United States Veterans Health Administration national program office leaders
Learning Health Systems, EarlyView.Abstract Background
The U.S. Veterans Health Administration (VHA) formed an Innovation Ecosystem that develops and disseminates innovative practices to enhance Veterans' health. Support of senior leadership and their perception of the innovation process is key to the Ecosystem's success.Jaifred Christian F. Lopez, Sallie Allgood, Kate Sheahan, Brandolyn White, M. Amy Kirshner, Suzanne Shirley, Madison Coffey, Amanda Milo, Sarah L. Cutrona, Laura Damschroder, Gemmae M. Fix, Andrea L. Nevedal, Caitlin M. Reardon, Marilla A. Opra Widerquist, Maria Arasim, Allen L. Gifford, Kathryn DeLaughter, George L. Jackson +17 morewiley +1 more sourceDisentangling informing participants from obtaining their consent
Learning Health Systems, EarlyView.Abstract Introduction
Pragmatic clinical trials conducted in the context of routine care frequently satisfy the regulatory criteria for a waiver of research consent. When they do, investigators and Institutional Review Boards might assume that there is no reason to communicate any information regarding the study to participants.Patricia Pearl O'Rourke, Joseph Ali, Judith Carrithers, David Magnus, Benjamin S. Wilfond, Sheana Bull, Laura M. Dember, Gail D'Onofrio, Julie Goldman, P. Michael Ho, Edward R. Melnick, Karen L. Staman, James A. Tulsky, Miguel A. Vazquez, Angelo Volandes, David Wendler +15 morewiley +1 more sourceDevelopment and validation of a computable phenotype for adolescent idiopathic scoliosis
Learning Health Systems, EarlyView.Abstract Introduction
There remains a lack of understanding of the etiology and treatment effectiveness for Adolescent idiopathic scoliosis (AIS). The objective of this study was to develop and validate a computable phenotype for patients with AIS to facilitate rapid learning through large‐scale observational research using real‐world data.Sarah B. Floyd, Ashley Mills, Jason Woloff, Christian Lowson, Coleman Hilton, Donna Oeffinger, Steven Hwang +6 morewiley +1 more sourceLearning Health System study designs for the evaluation of workforce interventions to cultivate eudaimonia (flourishing)
Learning Health Systems, EarlyView.Abstract Background
The Learning Health System (LHS) framework is designed to enhance healthcare by systematically integrating internal data and external evidence to promote quality, safety, and efficiency, aligning science, informatics, incentives, and culture for continuous improvement, innovation, and equity.Michael R. Cauley, Anna E. Berry, Carolyn M. Porta, Rachel K. Apple, Sunil Kripalani, Mark Linzer, Emily C. O'Brien, Russell L. Rothman, Christianne L. Roumie +8 morewiley +1 more sourceA Randomized, Double‐Blind, Placebo Controlled, Crossover Trial of incobotulinumtoxinA Treatment for Upper Limb Tremor
Movement Disorders Clinical Practice, EarlyView.Abstract Background
Proximal upper limb tremor is a common, functionally disabling condition. Medical therapy is often ineffective. IncobotulinumtoxinA can significantly improve tremor with minimal adverse effects. Objectives
We aimed to compare clinical, functional, and quality of life measures in patients with proximal upper limb tremor following ...Sai A. Nagaratnam, Duncan Wilson, Han‐Lin Chiang, Florence C.F. Chang, Jessica Qiu, Matthew Silsby, Alessandro F. Fois, Andrew Martin, Neil Mahant, Victor S.C. Fung, Hugo Morales‐Briceno +10 morewiley +1 more sourceNeuronal α‐Synuclein Disease Stage Progression over 5 Years
Movement Disorders, EarlyView.Abstract Background
Neuronal α‐synuclein disease (NSD) is defined by the presence of an in vivo biomarker of neuronal alpha‐synuclein (n‐asyn) pathology. The NSD integrated staging system (NSD‐ISS) for research describes progression across the disease continuum as stages 0 to 6.Tanya Simuni, Caroline Gochanour, Anuprita R. Nair, Michael C. Brumm, Christopher Coffey, Kathleen L. Poston, Lana M. Chahine, Daniel Weintraub, Caroline M. Tanner, Paulina Gonzalez‐Latapi, Catherine M. Kopil, Yuge Xiao, Sohini Chowdhury, Tien Dam, Gennaro Pagano, Diane Stephenson, Andrew Siderowf, Billy Dunn, Kenneth Marek, on behalf of the NSD Working Group the Parkinson's Progression Markers Initiative, Kenneth Marek, Caroline Tanner, Tanya Simuni, Andrew Siderowf, Douglas Galasko, Lana Chahine, Christopher Coffey, Kalpana Merchant, Kathleen Poston, Roseanne Dobkin, Tatiana Foroud, Brit Mollenhauer, Dan Weintraub, Ethan Brown, Karl Kieburtz, Mark Frasier, Todd Sherer, Sohini Chowdhury, Roy Alcalay, Aleksandar Videnovic, Duygu Tosun‐Turgut, Werner Poewe, Susan Bressman, Jan Hammer, Raymond James, Ekemini Riley, John Seibyl, Leslie Shaw, David Standaert, Sneha Mantri, Nabila Dahodwala, Michael Schwarzschild, Connie Marras, Hubert Fernandez, Ira Shoulson, Helen Rowbotham, Paola Casalin, Claudia Trenkwalder, Todd Sherer, Sohini Chowdhury, Mark Frasier, Jamie Eberling, Katie Kopil, Alyssa O'Grady, Maggie McGuire Kuhl, Leslie Kirsch, Tawny Willson, Emily Flagg, Tanya Simuni, Bridget McMahon, Craig Stanley, Kim Fabrizio, Dixie Ecklund, Trevis Huff, Tatiana Foroud, Laura Heathers, Christopher Hobbick, Gena Antonopoulos, John Seibyl, Kathleen Poston, Christopher Coffey, Chelsea Caspell‐Garcia, Michael Brumm, Brit Mollenhauer, Doug Galasko, Kalpana Merchant, Andrew Singleton, Tatiana Foroud, Thomas Montine, Caroline Tanner, Carlie Tanner, Ethan Brown, Lana Chahine, Roseann Dobkin, Monica Korell, Charles Adler, Roy Alcalay, Amy Amara, Paolo Barone, Bastiaan Bloem Susan Bressman, Kathrin Brockmann, Norbert Brüggemann, Lana Chahine, Kelvin Chou, Nabila Dahodwala, Alberto Espay, Stewart Factor, Hubert Fernandez, Michelle Fullard, Douglas Galasko, Robert Hauser, Penelope Hogarth, Shu‐Ching Hu, Michele Hu, Stuart Isaacson, Christine Klein, Rejko Krueger, Mark Lew, Zoltan Mari, Connie Marras, Maria Jose Martí, Nikolaus McFarland, Tiago Mestre, Brit Mollenhauer, Emile Moukheiber, Alastair Noyce, Wolfgang Oertel, Njideka Okubadejo, Sarah O'Shea, Rajesh Pahwa, Nicola Pavese, Werner Poewe, Ron Postuma, Giulietta Riboldi, Lauren Ruffrage, Javier Ruiz Martinez, David Russell, Marie H. Saint‐Hilaire, Neil Santos, Wesley Schlett, Ruth Schneider, Holly Shill, David Shprecher, Tanya Simuni, David Standaert, Leonidas Stefanis, Yen Tai, Caroline Tanner, Arjun Tarakad, Eduardo Tolosa, Aleksandar Videnovic, Susan Ainscough, Courtney Blair, Erica Botting, Isabella Chung, Kelly Clark, Ioana Croitoru, Kelly DeLano, Iris Egner, Fahrial Esha, May Eshel, Frank Ferrari, Victoria Kate Foster, Alicia Garrido, Madita Grümmer, Bethzaida Herrera, Ella Hilt, Chloe Huntzinger, Raymond James, Farah Kausar, Christos Koros, Yara Krasowski, Dustin Le, Ying Liu, Taina M. Marques, Helen Mejia Santana, Sherri Mosovsky, Jennifer Mule, Philip Ng, Lauren O'Brien, Abiola Ogunleye, Oluwadamilola Ojo, Obi Onyinanya, Lisbeth Pennente, Romina Perrotti, Michael Pileggi, Ashwini Ramachandran, Deborah Raymond, Jamil Razzaque, Shawna Reddie, Kori Ribb, Kyle Rizer, Janelle Rodriguez, Stephanie Roman, Clarissa Sanchez, Cristina Simonet, Anisha Singh, Elisabeth Sittig, Barbara Sommerfeld, Angela Stovall, Bobbie Stubbeman, Alejandra Valenzuela, Catherine Wandell, Diana Willeke, Karen Williams, Dilinuer Wubuli +205 morewiley +1 more source