Results 191 to 200 of about 108,162 (245)

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Australian Rural Surgical Workforce: A Policy Analysis. [PDF]

Aust J Rural Health
Carmichael GJ, Tranquille T, Di Tano V, Al-Sharea A, Kovoor JG, Jacob MO.   +5 more
europepmc   +1 more source

Institutional and Regional Variations in Access to Clinical Trials and Next-Generation Sequencing in Turkish Oncology Centers. [PDF]

Med Sci Monit
Güzel HG, Önder AH, İlhan Y, Balçık OY, Öztürk B.   +4 more
europepmc   +1 more source

Direct healthcare costs associated with reported patient safety incidents in two tertiary hospitals in Colombia. [PDF]

BMC Health Serv Res
Acevedo-Peña JR, Morón-Duarte LS, Chacón-Acevedo KR, Aguilar Ramírez DO, Torres Castro YM, Robayo Rodriguez SM, Gonzalez Bello AM, Avila Reina AY, Gomez Linares EB, Yomayusa Gonzalez N.   +9 more
europepmc   +1 more source

MASLD Management in Spain: A Nationwide Survey of Gastroenterologists Highlighting Gaps in Risk Assessment and Primary Care Coordination. [PDF]

J Clin Med
Jiménez-González C, Argos Vélez P, Cayón L, García-Garrido AB, Fontanillas Garmilla N, Cuadrado A, Iruzubieta P, Crespo J.   +7 more
europepmc   +1 more source

Insights on unmet needs from a survey among social media editors by EMEUNET. [PDF]

EULAR Rheumatol Open
Gupta L, Sadovici-Bobeica V, Kragstrup T, Gudu T, Farisogullari B, Rodríguez-Carrio J, Bergstra SA, Benavent D, Nikiphorou E, Carmona L.   +9 more
europepmc   +1 more source

Care-Seeking Behavior, Access to Treatment, and Under- Five Mortality in Kapolowe, a Remote Rural District in DRC: Findings from a Population Based Survey prior to iCCM Strengthening with Rectal Artesunate and Amoxicillin

Maseko T, Kanyamukenge DB, Khote FL, Sombola J, Matela B, Kakudji A, Kikunda G, Tevuzula VM, Mulangu AM, Sompwe EM, Hachizovu S, Nambozi M, Khondowe S, Baraka V, Rietveld H, Duparc S, Athersuch K, Lemey G, Bastiaens H, Manyando C, Makenga G, geertruyden JV, Mavoko HM.   +22 more
europepmc   +1 more source