Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Background: Concerns about the degree of compassion in health care have become a focus for national and international attention. However, existing research on compassionate care interventions provides scant evidence of effectiveness or the contexts in ...
Jackie Bridges +14 more
doaj +1 more source
Assessing the financial performance of hospitals in the Covid-19 crisis: a case study of a hospital in Tehran [PDF]
Background and aims: The Covid-19 was considered as a health shock and led to stochastic demand, which affected the financial performance of the hospitals in 2020.This study aimed to examine the financial performance of a non-training general and ...
Behnam Hassan-Nezhad +2 more
doaj
Comparative analysis of current payment system for hospital services in Serbia and projected payments under diagnostic related groups system in urology [PDF]
Background/Aim. Global budget per calendar year is a traditional method of funding hospitals in Serbia. Diagnose related groups (DGR) is a method of hospital payment based on classification of patients into groups with clinically similar ...
Babić Uroš +7 more
doaj +1 more source
Management of skin-sparing mastectomy: Results of a survey of German Hospitals [PDF]
Background: The aim of this study was to evaluate the current management of skin-sparing mastectomy in German hospitals and to determine its oncologic safety.
Dian, D. +4 more
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
The impact of the founding body on financial performance of Polish hospitals [PDF]
This article is devoted to assessing the impact of the hospital founding body on financial efficiency of the subordinated hospitals. The main aim of the study is to assess if there exist differences in financial performance of hospitals of different ...
Krzeczewski, Bartłomiej
core
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Primary Health Network critical success factors [PDF]
The Primary Health Network (PHN) program has the potential to make a significant positive difference in health outcomes for all Australians. PHN Discussion Paper #1 - Primary Health Network Critical Success Factors reflects on the lessons learnt from ...
Australian Healthcare and Hospitals Association
core
Catholic Hospital Ethics [PDF]
This is the final Report of the Commission on Ethical and Religious Directives for Catholic Hospitals - a study commission established by the Catholic Theological Society of America in June, 1971.
Commission on Ethical and Religious Directives for Catholic Hospitals
core +1 more source

