Results 1 to 10 of about 687,123 (260)

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces [PDF]

Frontiers in Immunology, 2021
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Britta Höchsmann, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt   +10 more
doaj   +3 more sources

Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry [PDF]

Cell Reports, 2015
Hepatitis C virus (HCV) enters human hepatocytes through a multistep mechanism involving, among other host proteins, the virus receptor CD81. How CD81 governs HCV entry is poorly characterized, and CD81 protein interactions after virus binding remain ...
Gisa Gerold, Felix Meissner, Janina Bruening, Kathrin Welsch, Paula M. Perin, Thomas F. Baumert, Florian W. Vondran, Lars Kaderali, Joseph Marcotrigiano, Abdul G. Khan, Matthias Mann, Charles M. Rice, Thomas Pietschmann   +12 more
doaj   +4 more sources

Characterization of DNA binding property of the HIV-1 host factor and tumor suppressor protein Integrase Interactor 1 (INI1/hSNF5). [PDF]

PLoS ONE, 2013
Integrase Interactor 1 (INI1/hSNF5) is a component of the hSWI/SNF chromatin remodeling complex. The INI1 gene is either deleted or mutated in rhabdoid cancers like ATRT (Atypical terratoid and rhabdoid tumor).
Supratik Das, Baisakhi Banerjee, Maidul Hossain, Muruganandan Thangamuniyandi, Saumya Dasgupta, Nipa Chongdar, Gopinatha Suresh Kumar, Gautam Basu   +7 more
doaj   +4 more sources

DHAV-1 Blocks the Signaling Pathway Upstream of Type I Interferon by Inhibiting the Interferon Regulatory Factor 7 Protein

Frontiers in Microbiology, 2021
Duck hepatitis A virus (DHAV), which mainly infects 1- to 4-week-old ducklings, has a fatality rate of 95% and poses a huge economic threat to the duck industry. However, the mechanism by which DHAV-1 regulates the immune response of host cells is rarely
Yalan Lai, Yalan Lai, Yalan Lai, Xiaoyan Xia, Xiaoyan Xia, Xiaoyan Xia, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Di Sun, Di Sun, Di Sun, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Xin-Xin Zhao, Juan Huang, Juan Huang, Juan Huang, Qun Gao, Qun Gao, Qun Gao, Bin Tian, Bin Tian, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Leichang Pan, Leichang Pan   +62 more
doaj   +1 more source

Receptors for Respiratory Syncytial Virus Infection and Host Factors Regulating the Life Cycle of Respiratory Syncytial Virus

Frontiers in Cellular and Infection Microbiology, 2022
Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections and responsible for a large proportion of mortality in children and the elderly. There are no licensed vaccines available to date.
Ziheng Feng, Ziheng Feng, Lili Xu, Lili Xu, Zhengde Xie, Zhengde Xie   +5 more
doaj   +1 more source

SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells

Frontiers in Microbiology, 2021
The accessory proteins of coronaviruses are essential for virus–host interactions and the modulation of host immune responses. It has been reported that accessory protein ORF3a encoded by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can ...
Ruiping Yang, Ruiping Yang, Qiong Zhao, Jingjing Rao, Feng Zeng, Shengren Yuan, Manshan Ji, Xiaoguang Sun, Jian Li, Jing Yang, Jing Yang, Jingwen Cui, Zhixiong Jin, Zhixiong Jin, Long Liu, Long Liu, Long Liu, Zhixin Liu, Zhixin Liu, Zhixin Liu   +19 more
doaj   +1 more source

Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation

Cell Reports, 2020
Summary: Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time course of herpes simplex virus 1 (HSV-1) infection was used to
Timothy K. Soh, Colin T.R. Davies, Julia Muenzner, Leah M. Hunter, Henry G. Barrow, Viv Connor, Clément R. Bouton, Cameron Smith, Edward Emmott, Robin Antrobus, Stephen C. Graham, Michael P. Weekes, Colin M. Crump   +12 more
doaj   +1 more source

Neuropilins: C-end rule peptides and their association with nociception and COVID-19

Computational and Structural Biotechnology Journal, 2021
Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2).
Amie Jobe, Ranjit Vijayan
doaj   +1 more source

Herpes Simplex Type 1 UL43 Multiple Membrane-Spanning Protein Increases Energy Metabolism in Host Cells through Interacting with ARL2

Cells, 2022
Non-essential proteins for viral replication affect host cell metabolism, while the function of the UL43 protein of herpes simplex virus 1 (HSV-1) is not clear.
Jianshan Deng, Zhiying Zhong, Chengxu Geng, Zhenning Dai, Weihan Zheng, Ziyue Li, Zi Yan, Jiaxin Yang, Wenfeng Deng, Wei Tan, Hanxiao Sun, Shiyu Li   +11 more
doaj   +1 more source

HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation

mBio, 2016
In addition to its ability to regulate HIV-1 promoter activation, the viral transactivator Tat also functions as a determinant of pathogenesis and disease progression by directly and indirectly modulating the host anti-HIV response, largely through the ...
Anna Lisa Remoli, Giulia Marsili, Edvige Perrotti, Chiara Acchioni, Marco Sgarbanti, Alessandra Borsetti, John Hiscott, Angela Battistini   +7 more
doaj   +1 more source