Results 11 to 20 of about 687,123 (260)

Chloride Intracellular Channel Protein 1 (CLIC1) Is a Critical Host Cellular Factor for Influenza A Virus Replication

Viruses
(1) Background: Influenza A Virus (IAV) uses host cellular proteins during replication in host cells. IAV infection causes elevated expression of chloride intracellular channel protein 1 (CLIC1) in lung epithelial cells, but the importance of this ...
Mahamud-ur Rashid, Kevin M. Coombs
doaj   +3 more sources

Host Factor Nucleophosmin 1 (NPM1/B23) Exerts Antiviral Effects against Chikungunya Virus by Its Interaction with Viral Nonstructural Protein 3

Microbiology Spectrum, 2023
Chikungunya virus (CHIKV) hijacks host cell machinery to support its replication. Nucleophosmin 1 (NPM1/B23), a nucleolar phosphoprotein, is one of the host proteins known to restrict CHIKV infection; however, the mechanistic details of the antiviral ...
Parvanendhu Pradeep, Krishnankutty Chandrika Sivakumar, Easwaran Sreekumar   +2 more
doaj   +3 more sources

Cloning and Expression of Truncated Protein of Epidermal Growth Factor-1 (EGFR-1) in Pichia Pastoris Yeast Host

مجله دانشکده پزشکی اصفهان, 2016
Background: Epidermal growth factor receptor (EGFR) plays a major role in the pathophysiology of a wide variety of solid tumors such as glioblastoma and breast cancer.
Javad Zavar-Reza, Nader Khaleghi, Ali Hatami, Masumeh Heidari, Reza Mansuri-Majumerd, Mohammad Hasan Sheikhha, Majid Mojarrad   +6 more
doaj   +2 more sources

HIV-1 Nef activates proviral DNA transcription by recruiting Src kinase to phosphorylate host protein Nef-associated factor 1 to compromise its viral restrictive function

Journal of Virology
HIV-1 accessory protein Nef is a multifunctional pathogenic factor that mediates immune evasion, enhances virion infectivity, antagonizes host restrictive factors, and promotes viral dissemination.
Tian-Jiao Fan, Chengzuo Xie, Lisha Li, Xia Jin, Jie Cui, Jian-Hua Wang   +5 more
doaj   +3 more sources

A HIV-1 Stimulating Host Factor Induced by HIV-1 Tat Protein [PDF]

Retrovirology, 2005
The HIV-1 Tat gene is required for virus replication and disease. Tat was reported to be released from infected cells. Recombinant soluble Tat may be taken up by many cell types and transported to the nucleus as an active transcription factor leading to upregulation of viral replication in bystander cells.
Pauza Dave, Ruckwardt Tracy, Berg Shannon, Tikhonov Ilia   +3 more
doaj   +2 more sources

Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation

Viruses, 2022
The HIV-1 envelope glycoprotein (Env) is an essential structural component of the virus, serving as the receptor-binding protein and principal neutralizing determinant. Env trimers are incorporated into developing particles at the plasma membrane of infected cells. Incorporation of HIV-1 Env into particles in T cells and macrophages is regulated by the
Boris Anokhin, Paul Spearman
openaire   +3 more sources

Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA [PDF]

Molecular Cell, 2020
The causative virus of the COVID-19 pandemic, SARS-CoV-2, uses its nonstructural protein 1 (Nsp1) to suppress cellular, but not viral, protein synthesis through yet unknown mechanisms. We show here that among all viral proteins, Nsp1 has the largest impact on host viability in the cells of human lung origin. Differential expression analysis of mRNA-seq
Yuan, Shuai, Peng, Lei, Park, Jonathan J., Hu, Yingxia, Devarkar, Swapnil C., Dong, Matthew B., Shen, Qi, Wu, Shenping, Chen, Sidi, Lomakin, Ivan B., Xiong, Yong   +10 more
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Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) – splicing factor axis [PDF]

Journal of General Virology, 2020
The infectious life cycle of human papillomaviruses (HPVs) is tightly linked to keratinocyte differentiation. Evidence suggests a sophisticated interplay between host gene regulation and virus replication. Alternative splicing is an essential process for host and viral gene expression, and is generally upregulated by serine arginine-rich splicing ...
Sarah Mole, Arwa Ali A. Faizo, Hegel Hernandez-Lopez, Megan Griffiths, Andrew Stevenson, Sally Roberts, Sheila V Graham   +6 more
openaire   +2 more sources

The barrier-to-autointegration protein is a host factor for HIV type 1 integration [PDF]

Proceedings of the National Academy of Sciences, 1998
In vivo , retroviral integration is mediated by a large nucleoprotein complex, termed the preintegration complex (PIC). PICs isolated from infected cells display in vitro integration activity. Here, we analyze the roles of different host cell factors in the structure and function of HIV type 1 (HIV-1 ...
H, Chen, A, Engelman
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Accessory Regulatory Proteins of HIV-1 and Host Restriction Factors Interactions [PDF]

Biomedical Journal of Scientific & Technical Research, 2020
When the human immunodeficiency virus type 1 was cloned and sequenced for first time, the researchers were surprised...
openaire   +1 more source