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Comprehensive analysis of liquid–liquid phase separation propensities of HSV‐1 proteins and their interaction with host factors

Journal of Cellular Biochemistry, 2023
AbstractIn recent years, it has been shown that the liquid–liquid phase separation (LLPS) of virus proteins plays a crucial role in their life cycle. It promotes the formation of viral replication organelles, concentrating viral components for efficient replication and facilitates the assembly of viral particles.
Sushma Subedi   +4 more
openaire   +2 more sources

Host Cell Factor-1 and E2F4 Interact Via Multiple Determinants in Each Protein

Molecular and Cellular Biochemistry, 2006
Host Cell Factor (HCF-1) is a conserved, essential protein initially identified as a co-regulator for the Herpes Simplex Virus transactivator VP16. HCF-1 is variously involved in regulating transcription, splicing, cell proliferation and cytokinesis; however, its mechanisms of action remain unknown.
Jozo, Knez   +3 more
openaire   +2 more sources

Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus

Journal of Virology
Covalently closed circular DNA plays a key role for the persistence of hepatitis B virus (HBV) since it serves as the template for viral transcription. Identification of transcription factors that regulate HBV transcription not only provides insights into molecular mechanisms of viral life cycle regulation but may also provide potential ...
Zhongliang Shen   +14 more
openaire   +2 more sources

Protein synthesis in tumor host. II. Increased activity of peptide elongation factor 1 in experimental rat tumors and in host liver.

Neoplasma, 1979
Both peptide elongation factors were purified from Zajdela and Walker tumors and from the host and normal liver. The activity of peptide elongation factor 1 from tumor tissues in promoting the binding of phenylalanyl-tRNA to ribosomes was significantly higher than that of normal liver.
Z, Dusek, J, Hradec
openaire   +1 more source

Protein interactions in the herpes simplex virus type 1 VP16-induced complex: VP16 peptide inhibition and mutational analysis of host cell factor requirements

Journal of Virology, 1997
The herpes simplex virus VP16 protein functions as a potent transcriptional activator and targets DNA sites with the consensus TAATGARAT present in all the viral immediate-early gene promoters. To do so, VP16 directs assembly of a multiprotein complex involving two cellular proteins, host cell factor (HCF) and the Oct-1 DNA-binding transcription factor.
K A, Simmen   +8 more
openaire   +2 more sources

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Resolution of the dimer bridge of Minute Virus of Mice : roles of the viral NS-1 protein and a host cell factor

2009
Previous characterization of the terminal sequences of the Minute Virus of Mice (MVM) genome demonstrated that the right hand palindrome contains two sequences, each the inverted complement of the other. However, the left hand palindrome was shown to exist as a unique sequence (Astell et al, Virology 54:171-177, 1985).
openaire   +1 more source

PROTAC targeted protein degraders: the past is prologue

Nature Reviews Drug Discovery, 2022
Miklos Bekes   +2 more
exaly  

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