Results 31 to 40 of about 687,123 (260)

Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.

PLoS Biology, 2018
The threat of viral pandemics demands a comprehensive understanding of evolution at the host-pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host ...
Angela M Phillips, Anna I Ponomarenko, Kenny Chen, Orr Ashenberg, Jiayuan Miao, Sean M McHugh, Vincent L Butty, Charles A Whittaker, Christopher L Moore, Jesse D Bloom, Yu-Shan Lin, Matthew D Shoulders   +11 more
doaj   +1 more source

Comparative Transcriptomics Highlights the Role of the Activator Protein 1 Transcription Factor in the Host Response to Ebolavirus [PDF]

Journal of Virology, 2017
ABSTRACT Ebolavirus and Marburgvirus comprise two genera of negative-sense single-stranded RNA viruses that cause severe hemorrhagic fevers in humans. Despite considerable research efforts, the molecular events following Ebola virus (EBOV) infection are poorly understood.
James W, Wynne, Shawn, Todd, Victoria, Boyd, Mary, Tachedjian, Reuben, Klein, Brian, Shiell, Megan, Dearnley, Alexander J, McAuley, Amanda P, Woon, Anthony W, Purcell, Glenn A, Marsh, Michelle L, Baker   +11 more
openaire   +2 more sources

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement.

PLoS ONE, 2007
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Brian Stevenson, Henry A Choy, Marija Pinne, Matthew L Rotondi, M Clarke Miller, Edward Demoll, Peter Kraiczy, Anne E Cooley, Trevor P Creamer, Marc A Suchard, Catherine A Brissette, Ashutosh Verma, David A Haake   +12 more
doaj   +1 more source

SARS-CoV-2 helicase NSP13 hijacks the host protein EWSR1 to promote viral replication by enhancing RNA unwinding activity

Infectious Medicine, 2022
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and has led to a global coronavirus disease 2019 (COVID-19) pandemic.
Hongxiang Zeng, Xiang Gao, Gang Xu, Shengyuan Zhang, Lin Cheng, Tongyang Xiao, Wenhong Zu, Zheng Zhang   +7 more
doaj   +1 more source

IL-10 promoter transactivation by the viral K-RTA protein involves the host-cell transcription factors, specificity proteins 1 and 3 [PDF]

Journal of Biological Chemistry, 2018
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 (HHV-8) causes a persistent infection, presenting latent and lytic replication phases during its life cycle. KSHV-related diseases are associated with deregulated expression of inflammatory cytokines, including IL-6 and IL-10, but the mechanisms underlying this dysregulation are unclear.
Masanori, Miyazawa, Kohji, Noguchi, Mana, Kujirai, Kazuhiro, Katayama, Satoshi, Yamagoe, Yoshikazu, Sugimoto   +5 more
openaire   +2 more sources

Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage

Frontiers in Immunology, 2018
The opportunistic fungal pathogen Aspergillus fumigatus can cause life-threatening infections, particularly in immunocompromised patients. Most pathogenic microbes control host innate immune responses at the earliest time, already before infiltrating ...
Prasad Dasari, Iordana A. Shopova, Maria Stroe, Dirk Wartenberg, Hans Martin-Dahse, Niklas Beyersdorf, Peter Hortschansky, Stefanie Dietrich, Stefanie Dietrich, Zoltán Cseresnyés, Marc Thilo Figge, Marc Thilo Figge, Martin Westermann, Christine Skerka, Axel A. Brakhage, Axel A. Brakhage, Peter F. Zipfel, Peter F. Zipfel   +17 more
doaj   +1 more source

Structural basis of host protein hijacking in human T-cell leukemia virus integration

Nature Communications, 2020
Integration of the reverse-transcribed viral DNA into host chromosomes is a critical step in the life-cycle of retroviruses such as the human T-cell leukemia virus type-1 (HTLV-1).
Veer Bhatt, Ke Shi, Daniel J. Salamango, Nicholas H. Moeller, Krishan K. Pandey, Sibes Bera, Thomas E. Bohl, Fredy Kurniawan, Kayo Orellana, Wei Zhang, Duane P. Grandgenett, Reuben S. Harris, Anna C. Sundborger-Lunna, Hideki Aihara   +13 more
doaj   +1 more source

Interaction of HIV-1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV-1 replication

Retrovirology, 2019
Background The different interactions between viral proteins and cellular host proteins are required for efficient replication of HIV-1. Various reports implicated host cellular proteins as a key factor that either interact directly with HIV-1 integrase (
Pooja Yadav, Souvik Sur, Dipen Desai, Smita Kulkarni, Vartika Sharma, Vibha Tandon   +5 more
doaj   +1 more source

Help or Hinder: Protein Host Factors That Impact HIV-1 Replication

Viruses
Interactions between human immunodeficiency virus type 1 (HIV-1) and the host factors or restriction factors of its target cells determine the cell’s susceptibility to, and outcome of, infection. Factors intrinsic to the cell are involved at every step of HIV-1’s replication cycle, contributing to productive infection and replication, or severely ...
Michael Rameen Moezpoor, Mario Stevenson
openaire   +3 more sources

TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion

Virology, 2008
TULA, a recently identified UBA- and SH3-containing protein, has previously been shown to regulate cell signaling through protein tyrosine kinases. In order to search for novel functions of TULA, we identified, using mass spectrometry, proteins associated with TULA.
Smirnova, Ev, Collingwooda, Ts, Bisbal, C., Tsygankovae, Om, Bogusha, M., Meinkothe, Jl, Hendersona, Ee, Annana, Rs, Tsygankov, Ay   +8 more
openaire   +2 more sources