Results 41 to 50 of about 687,123 (260)

Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition

Frontiers in Microbiology, 2021
Coronaviruses have brought severe challenges to public health all over the world in the past 20years. SARS-CoV-2, the causative agent of the COVID-19 pandemic that has led to millions of deaths, belongs to the genus beta-coronavirus.
Shuai Yuan, Shravani Balaji, Ivan B. Lomakin, Yong Xiong   +3 more
doaj   +1 more source

Identification of adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression. [PDF]

PLoS ONE, 2013
The NS1 protein of influenza A virus (IAV) is a multifunctional virulence factor. We have previously characterized gain-of-function mutations in the NS1 protein arising from the experimental adaptation of the human isolate A/Hong Kong/1/1968(H3N2) (HK ...
Nicole Forbes, Mohammed Selman, Martin Pelchat, Jian Jun Jia, Alain Stintzi, Earl G Brown   +5 more
doaj   +1 more source

T-Cell Immunoglobulin and Mucin Domain 1 (TIM-1) Is a Functional Entry Factor for Tick-Borne Encephalitis Virus

mBio, 2022
Tick-borne encephalitis virus (TBEV) is the causative agent of a potentially fatal neurological infection affecting humans. The host factors required for viral entry have yet to be described.
Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, Xian-En Zhang, Zongqiang Cui   +11 more
doaj   +1 more source

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1

Proceedings of the National Academy of Sciences, 2023
Zoonotic poxviruses such as mpox virus (MPXV) continue to threaten public health safety since the eradication of smallpox. Vaccinia virus (VACV), the prototypic poxvirus used as the vaccine strain for smallpox eradication, is the best-characterized member of the poxvirus family.
Junda Zhu, Xintao Gao, Yijing Li, Zihui Zhang, Shijie Xie, Shuning Ren, Yarui Li, Hua Li, Kang Niu, Shufang Fu, Yining Deng, Yinü Li, Bernard Moss, Wenxue Wu, Chen Peng   +14 more
openaire   +2 more sources

Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins

Frontiers in Microbiology, 2018
Influenza A virus exploits multiple host proteins during infection. To define the virus–host interactome, our group conducted a proteomics-based screen and identified 299 genes that contributed to virus replication and 24 genes that were antiviral.
Shuhei Sammaibashi, Seiya Yamayoshi, Yoshihiro Kawaoka, Yoshihiro Kawaoka, Yoshihiro Kawaoka   +4 more
doaj   +1 more source

Protein Interactions Network of Porcine Circovirus Type 2 Capsid With Host Proteins

Frontiers in Microbiology, 2020
Virus-host interaction is a tug of war between pathogenesis and immunity, followed by either activating the host immune defense system to eliminate virus or manipulating host immune control mechanisms to survive and facilitate virus propagation ...
Jianwei Zhou, Hanying Li, Tianqi Yu, Jiarong Li, Weiren Dong, Nishant Kumar Ojha, Yulan Jin, Jinyan Gu, Jiyong Zhou, Jiyong Zhou   +9 more
doaj   +1 more source

Running Loose or Getting Lost: How HIV-1 Counters and Capitalizes on APOBEC3-Induced Mutagenesis through Its Vif Protein

Viruses, 2012
Human immunodeficiency virus-1 (HIV-1) dynamics reflect an intricate balance within the viruses’ host. The virus relies on host replication factors, but must escape or counter its host’s antiviral restriction factors.
Christel Kamp, Dieter Häussinger, Jörg Zielonka, Carsten Münk, Björn-Erik O. Jensen   +4 more
doaj   +1 more source

Interactions of HIV-1 Capsid with Host Factors and Their Implications for Developing Novel Therapeutics

Viruses, 2021
The Human Immunodeficiency Virus type 1 (HIV-1) virion contains a conical shell, termed capsid, encasing the viral RNA genome. After cellular entry of the virion, the capsid is released and ensures the protection and delivery of the HIV-1 genome to the ...
Shentian Zhuang, Bruce E. Torbett
doaj   +1 more source

Mixed Lineage Leukemia 5 (MLL5) Protein Regulates Cell Cycle Progression and E2F1-responsive Gene Expression via Association with Host Cell Factor-1 (HCF-1) [PDF]

Journal of Biological Chemistry, 2013
Trithorax group proteins methylate lysine 4 of histone 3 (H3K4) at active gene promoters. MLL5 protein, a member of the Trithorax protein family, has been implicated in the control of the cell cycle progression; however, the underlying molecular mechanism(s) have not been fully determined.
Peipei, Zhou, Zhilong, Wang, Xiujie, Yuan, Cuihong, Zhou, Lulu, Liu, Xiaoling, Wan, Feng, Zhang, Xiaodan, Ding, Chuangui, Wang, Sidong, Xiong, Zhen, Wang, Jinduo, Yuan, Qiang, Li, Yan, Zhang   +13 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source