Results 51 to 60 of about 687,123 (260)
PLOS Pathogens, 2020 Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon-inducible protein 16 (IFI16) restricts retroviral gene expression by sequestering the transcription ...
Matteo Bosso +16 more
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Screening and identification of host cellular factors interaction with immediate-early protein ICP22 of herpes simplex virus type 1 [PDF]
BMC Proceedings, 2011 Herpes simplex virus type 1 (HSV-1) is a common and widely studied human pathogen that can replicate in epithelial cells and other cells of the host or alternatively can remain latent in peripheral neurons. ICP22 consists of 420 residues and is encoded by a spliced mRNA transcribed from the US1 gene. It is necessary for efficient HSV-1 growth in animal
Xing, Junji +5 more
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By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Viruses, 2015 The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1
Oliver T. Fackler
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways
Asian Pacific Journal of Tropical Medicine, 2018 Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus (CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 ...
Swati Gupta +5 more
doaj +1 more source
miRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. [PDF]
PLoS ONE, 2014 Primary monocytes are refractory to HIV-1 infection and become permissive upon differentiation into monocyte-derived dendritic cells (MDDCs) or macrophages. Multiple mechanisms have been proposed to interpret HIV-1 restriction in monocytes.
Li Ma +4 more
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Immunoprecipitation and Western blot-based detection of protein O-GlcNAcylation in cells
STAR Protocols, 2022 Summary: Detection of protein O-GlcNAcylation could be challenging. By using the host-cell factor 1 (HCF-1), a known O-GlcNAcylated protein, we immunoprecipitated HCF-1 from transfected HEK293T cells or endogenous HCF-1 from HeLa cells to detect its O ...
Oumaima Ahmed +7 more
doaj +1 more source
The metastasis-associated protein-1 gene encodes a host permissive factor for schistosomiasis, a leading global cause of inflammation and cancer [PDF]
Hepatology, 2011 Abstract: Schistosoma haematobium is responsible for two-thirds of the world's 200 million to 400 million cases of human schistosomiasis.
Sujit S, Nair +12 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source