Results 211 to 220 of about 88,485 (243)

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Gender-specific symptom outcomes on cariprazine treatment: a 12-month naturalistic longitudinal follow-up study in schizophrenia. [PDF]

Front Psychiatry
Carmassi C, Pedrinelli V, Bordacchini A, Rimoldi B, Parrini L, Bertelloni CA, Dell'Oste V.   +6 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Effects of an 8-week self-compassion-based mental preparation program on mood states and 3,000 m performance in cadet cross-country athletes. [PDF]

Front Psychol
Bouallagui N, Goumni C, Hammami A, Driss A, Khalifa R, Hammami R, Amar IB.   +6 more
europepmc   +1 more source

Short-Term Psychological and Physiological Changes Following Coffee Aroma Exposure: A Multimodal Assessment. [PDF]

Nutrients
Fukatsu M, Tsuchiya Y, Inoue Y.
europepmc   +1 more source

Disentangling shared and unique effects of parenting on psychopathology: Evidence from two prospective, genetically sensitive cohort studies. [PDF]

JCPP Adv
Richmond-Rakerd LS, Khalifeh L, Burt SA, Ganiban JM, Hsu RE, Hyde LW, Lee S, Leve LD, Natsuaki MN, Neiderhiser JM, Reiss D, Shaw DS, Suarez GL, Wertz J.   +13 more
europepmc   +1 more source

The Role of Emotion Dysregulation, Impulsiveness and Rumination in Psychopathology: Evidence from an Italian Sample of Adolescents and Young Adults. [PDF]

Brain Sci
Aprile SF, Avanzato C, Alù F, Concerto C, Cutrufelli P, Mineo L, Privitera G, Petralia A, Rodolico A, Caraci F, Signorelli MS.   +10 more
europepmc   +1 more source

Psychometric properties of JPSS (Japanese parenting style scale) between mother and father in West Java, Indonesia. [PDF]

Front Psychol
Jatnika R, Agustiani H, Rubiyanti Y, Syahlaa S, Muliadi R, Sahrani FT, Putri UNA, Okubo K.   +7 more
europepmc   +1 more source