Results 51 to 60 of about 11,664 (290)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Renewable energy hosting capacity assessment in distribution networks based on multi‐strategy improved whale optimization algorithm

IET Renewable Power Generation
The increasing penetration of distributed renewable energy poses significant challenges to the safety and stability of distribution system, rendering the renewable energy hosting capacity of distribution networks a major concern.
Chongwu Dong, Tao Yu, Zhenning Pan, Yufeng Wu, Ziyao Wang, Yipeng Wang, Keying Wang   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Estimation of Photovoltaic Hosting Capacity Due to the Presence of Diverse Harmonics in an Active Distribution Network

IEEE Access
Renewable distributed energy resources are the solution to rising power demand, but their integration is a difficult technological undertaking that requires careful planning.
Sourav Kumar Sahu, Swati Kumari, Debomita Ghosh, Soham Dutta   +3 more
doaj   +1 more source

Cooperative multi-agent deep reinforcement learning based decentralized framework for dynamic renewable hosting capacity assessment in distribution grids

Energy Reports, 2023
Renewable hosting capacity (RHC) means the total renewable power that can be integrated into the power grid without violation of network constraints. In this paper, a cooperative multi-agent deep reinforcement learning (CMADRL) based decentralized method
Xu Xu, Xiaoyang Chen, Jia Wang, Lurui Fang, Fei Xue, Eng Gee Lim   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Quality of healthcare for children with severe acute malnutrition in a refugee setting: cross-sectional study in West Nile Region, Uganda

BMJ Open, 2020
Objectives 5.0 million annual deaths in low-income and middle-income countries are due to poor quality of care (QOC). We evaluated the QOC provided to malnourished children in West Nile Region in Uganda.Design Cross-sectional study.Setting West Nile ...
Marzia Lazzerini, Humphrey Wanzira, Peter Lochoro, Giovanni Putoto, Amos Ndunguste, Jerry Ictho, Ambrose Katungi, Ilaria Mariani   +7 more
doaj   +1 more source

EV and PV Capacity Management to Increase Hosting Capacity

, 2023
International audienceAs more electric vehicles (EVs) and photovoltaic (PV) systems are integrated into distribution systems, managing their capacity becomes critical for grid operation and planning.
Alvarez-Hérault, Marie-Cécile
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