Results 251 to 260 of about 701,414 (343)

The Ecological Impacts of Dry and Hot Shocks in the Land of Midnight Sun. [PDF]

Glob Chang Biol
Gu L, Gao B.
europepmc   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

A near-infrared Sn-Pb perovskite imager with monolithic integration. [PDF]

Light Sci Appl
Ge C, Deng C, Zhu J, Zhu Y, Xu Q, Jiang B, Chen L, Liu Y, Song B, Fu P, Chen C, Gao L, Tang J.   +12 more
europepmc   +1 more source

A Time‐Programmed Bilayer Wound Dressing for Dynamic Microenvironment Modulation and Full‐Thickness Regeneration in Diabetic Wounds

Advanced Science, EarlyView.
The Polyphenol+PDGF‐BB scaffold fabrication (Panel A) and its dual wound healing effects (Panel B: anti‐inflammation and accelerated tissue remodeling). ABSTRACT Chronic diabetic wounds suffer from dysfunctional repair programs due to accumulated advanced glycation end products (AGEs) and persistent inflammation in hyperglycemic microenvironments ...
Lei Yi, Wanqian Li, Ying Duanmu, Zihan Zhang, Shixuan Chen, Shichu Xiao, Lei Du, Miaomiao Wei   +7 more
wiley   +1 more source

Screened axio-dilaton cosmology: novel forms of early dark energy. [PDF]

Eur Phys J C Part Fields
Smith A, Brax P, Bruck CV, Burgess CP, Davis AC.   +4 more
europepmc   +1 more source

Food‐Activated Microneedle Sensor for Real‐Time, Colorimetric Spoilage Monitoring of Pre‐Packaged Food

Advanced Science, EarlyView.
A microneedle spoilage sensor for packaged food products is presented. The sensor is composed entirely of food‐derived agents, integrated together using a novel material processing approach. This resultant platform nondestructively reports spoilage state in real‐time through a colorimetric output.
Shadman Khan, Akansha Prasad, Mahum Javed, Roderick MacLachlan, Carlos D. M. Filipe, Tohid F. Didar   +5 more
wiley   +1 more source

Surface-plasmon control of ultrafast energy-relaxation modes in photoexcited Au nanorods probed by time-resolved single-particle X-ray imaging. [PDF]

Nat Commun
Park E, Jung C, Hwang J, Shin J, Lee SY, Lee H, Heo SP, Nam D, Kim S, Kim MS, Kim KS, Eom IT, Ihm Y, Noh DY, Song C.   +14 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Multi-messenger dynamic imaging of laser-driven shocks in water using a plasma wakefield accelerator. [PDF]

Nat Commun
Balcazar MD, Tsai HE, Ostermayr TM, Campbell P, Trantham MR, Albert F, Chen Q, Colgan C, Dyer GM, Eisentraut Z, Esarey E, Grace ES, Greenwood B, Gonsalves AJ, Hakimi S, Jacob R, Kettle B, King P, Krushelnick K, Lemos N, Los EE, Ma Y, Mangles SPD, Nees J, Pagano IM, Schroeder CB, Simpson RA, Vazquez AV, van Tilborg J, Geddes CGR, Thomas AGR, Kuranz CC.   +31 more
europepmc   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source