Results 271 to 280 of about 701,414 (343)

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Gridography tractography reveals communication between key areas from global workspace and integrated information theories of consciousness. [PDF]

Sci Rep
Lori N, Machado J.
europepmc   +1 more source

AI‐Directed 3D Printing of Hierarchical Polyurethane Foams

Advanced Science, EarlyView.
Digitally guided direct ink writing, combined with AI‐generated design, enables the fabrication of hierarchical polyurethane foams with tunable multiscale porosity. This approach produces architected foams featuring interconnected open‐cell networks and tailored mechanical properties, advancing the development of adaptive, high‐performance materials ...
Dhanush Patil, Jie Tian, Kun Jiang, Clarissa Westover, Sri Vaishnavi Thummalapalli, Arunachalam Ramanathan, Arpita Shome, Natalie Crutchfield, M. Taylor Sobczak, Sean Lee, Hongyue Sun, Elizabeth J. Brisbois, Hitesh Handa, Timothy E. Long, Xianqiao Wang, Kenan Song   +15 more
wiley   +1 more source

Mid-day photomixotrophy by <i>Roseiflexus</i> spp. and implications for the ¹³C content of hot spring cyanobacterial mats. [PDF]

Appl Environ Microbiol
Moran JJ, Ilhardt PD, Couvillion SP, Lipton MS, Metz TO, Tolic N, Bryant DA, Ward DM.   +7 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Chrono-physiological management protocol in form of simultaneous shifting of lighting-cycle and feeding-time can enhance production performance of heat-stressed goat kids. [PDF]

J Anim Sci Technol
Al-Badwi MA, Samara EM, Bahadi MA, Abdoun KA, Swelum AA, Al-Owaimer AN, Al-Haidary AA.   +6 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Formation of high-aspect-ratio nanocavity in LiF crystal using a femtosecond X-ray free-electron laser pulse. [PDF]

Nat Commun
Makarov SS, Zhakhovsky VV, Grigoryev SY, Chuprov P, Pikuz TA, Inogamov NA, Khokhlov VA, Petrov YV, Perov EA, Shepelev V, Shobu T, Tominaga A, Rapp L, Juodkazis S, Makita M, Nakatsutsumi M, Preston TR, Appel K, Konopkova Z, Cerantola V, Brambrink E, Schwinkendorf JP, Mohacsi I, Vozda V, Hajkova V, Burian T, Chalupsky J, Juha L, Ozaki N, Kodama R, Zastrau U, Rode AV, Pikuz SA.   +32 more
europepmc   +1 more source

Grain Boundary Segregation Suppresses Local Short‐Range Ordering in Nanocrystalline High‐Entropy Alloys

Advanced Science, EarlyView.
Multicomponent alloys, such as high‐entropy alloys (HEAs), are considered to be in a random solid solution. However, recent studies have shown that short‐range ordering (SRO) is prevalent in these HEAs due to multipairwise interactions among the constituent elements, which can be deleterious.
Moses A. Adaan‐Nyiak, Mack Cleveland, Benjamin Hewitt, Ericmoore Jossou, Mehmet Topsakal, Simerjeet K. Gill, Sooyeon Hwang, Kim Kisslinger, Ahmed A. Tiamiyu   +8 more
wiley   +1 more source

Diffusion-induced enhanced photoresponsivity and detectivity in an Ag₂S/In₂Se₃ heterostructure for a UV-visible photodetector: an experimental and computational analysis. [PDF]

Nanoscale Adv
Kumar PC, Mohanty S, Supriya S, Swain R, Kumar J, Naik R.   +5 more
europepmc   +1 more source