Results 151 to 160 of about 246,046 (315)
A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands
ChemMedChem, EarlyView.A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova +15 more
wiley +1 more source
Critical appraisal of paroxetine for the treatment of vasomotor symptoms
International Journal of Women's Health, 2015 Dana G Carroll,1,2 Katelin M Lisenby,1,2 Tracy L Carter3 1Department of Pharmacy Practice, Harrison School of Pharmacy, Auburn University, Auburn, AL, USA; 2Department of Family Medicine, College of Community Health Sciences, University of Alabama ...
Carroll DG, Lisenby KM, Carter TL
doaj
Hormone variability and hot flash experience: Results from the midlife women's health study. [PDF]
Maturitas, 2019 Chiang C +5 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen +8 more
wiley +1 more source
Automatic Detection of Hot Flash Occurrence and Timing from Skin Conductance Activity. [PDF]
Annu Int Conf IEEE Eng Med Biol Soc, 2018 Forouzanfar M +3 more
europepmc +1 more source
Profiling Social Entrepreneurship Orientation Through Machine Learning Predictive Modeling
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT This study examines the prediction of Social Entrepreneurship Orientation (SEO) in youth using machine learning techniques to generate a robust predictive model. Drawing on a large cross‐country survey of European youth, results indicate that cognitive–attitudinal indicators—such as concern for environmental goals, purpose‐driven motivation ...
Ángel Peiró‐Signes +2 more
wiley +1 more source
Evaluation of Fluoxtinfor Treatm Ent of Menopausal Hot Flashes
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2004 Introduction: Hot flashes can be prominent problem in menopausal women. The treatment of hot flashes is hormonal thrapies but in some patients that are unable to use estrogen other treating hot flashes are required.
L Sakhavat, MA Karimzadeh-Maibodi
doaj
Corrigendum to "A Hop Extract Lifenol® Improves Postmenopausal Overweight, Osteoporosis, and Hot Flash in Ovariectomized Rats". [PDF]
Evid Based Complement Alternat Med, 2018 Ban YH +11 more
europepmc +1 more source
Deep Underground Science and Engineering, EarlyView.Through shear–tensile creep tests and viscoelastic modeling, the fracture evolution of thick soft protective layers is clarified. Results show thickness‐dependent rheological failure modes that govern four types of roof water inrush, providing a mechanism‐based framework for hazard prediction and control. Abstract In the Jurassic coal‐bearing strata of
Mengnan Liu +4 more
wiley +1 more source