Results 91 to 100 of about 1,253,683 (304)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Incidence of Hot Flashes among Peri- and Postmenopausal Women in India: A Clinico-demographic Analysis

Journal of Mid-Life Health
Background: Vasomotor symptoms (VMS), such as hot flashes, commonly affect menopausal women aged 40–60 years and can impact the quality of life due to associated sleep disorders and mood changes.
Mohandas Shobhana, Jyothi Ramesh Chandran, Neelam Aggarwal, Seema Sharma, Revty Jankiram, Anju Soni, Jyoti Jaiswal, Sudha Sharma, S. Lakshmi, Sheela Mane, Meeta Singh, Sushma Verma, Ritu Jain   +12 more
doaj   +1 more source

The Effect of Folic Acid on Menopausal Hot Flashes : A Randomized Clinical Tria [PDF]

Journal of Caring Sciences, 2013
Introduction: The use of alternative therapies for the treatment of menopausal hot flashes has increased due to the serious risk of hormone therapy. Most alternative therapies have not been accepted by women.
Soheila Bani, Shirin Hasanpour, Leila Farzad Rik, Hadi Hasankhani, Seiedeh Hajar Sharami   +4 more
doaj   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Apollo-Soyuz pamphlet no. 9: General science [PDF]

, 1977
The objectives and planning activities for the Apollo-Soyuz mission are summarized. Aspects of the space flight considered include the docking module and launch configurations, spacecraft orbits, and weightlessness.
From, T. P., Page, L. W.
core   +1 more source

Hydrodynamic simulations of shell convection in stellar cores

, 2011
Shell convection driven by nuclear burning in a stellar core is a common hydrodynamic event in the evolution of many types of stars. We encounter and simulate this convection (i) in the helium core of a low-mass red giant during core helium flash leading
A Chieffi, A Weiss, CA Meakin, CA Meakin, F Herwig, HJS Fernando, J Montalbán, L Siess, L Siess, M Mocák, M Mocák, N Iwamoto, NH Brummell, S Cassisi, SW Campbell, TM Brown   +15 more
core   +1 more source

Treatment of symptoms of the menopause: an endocrine society clinical practice guideline [PDF]

, 2015
Objective: The objective of this document is to generate a practice guideline for the management and treatment of symptoms of the menopause. Participants: The Treatment of Symptoms of the Menopause Task Force included six experts, a methodologist, and
Davis, Susan R., Gompel, Anne, Lumsden, Mary Ann, Murad, M. Hassan, Pinkerton, JoAnn V., Santen, Richard J., Stuenkel, Cynthia A.   +6 more
core   +1 more source

Comparison of gabapentin with estrogen for treatment of hot flashes in post-menopausal women

Journal of Research in Pharmacy Practice, 2013
Objective: Various non-hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective and well-tolerated treatment modality.
Zahra Allameh, Safoura Rouholamin, Sonia Valaie   +2 more
doaj   +1 more source

Thermoelectric Property Mapping for High‐Performance Integrated MgAgSb‐MgCuSb System

Advanced Science, EarlyView.
From the property mapping of the MgAgSb–MgCuSb system, both thermoelectric materials and corresponding interface materials are optimized: Ag‐rich compositions provide higher PF and zT, whereas Cu‐rich side yields superior transport properties and low contact resistance.
Jiankang Li, Airan Li, Longquan Wang, Xinzhi Wu, Raju Chetty, Takao Mori   +5 more
wiley   +1 more source

Fluorinated Hypoxia‐Responsive Aza‐BODIPY for NIR‐II FL/19F MR/PA Imaging and Phototherapy of Lung Cancer

Advanced Science, EarlyView.
Fluorinated N‐oxide aza‐BODIPY nanoemulsions integrate fluorination‐driven molecular design with co‐assembly in fluorinated oil for multimodal imaging‐guided phototherapy. The co‐assembly redshifts fluorescence into the NIR‐II window for deep‐tissue imaging and provides a unified 19F signal for background‐free, quantitative MRI.
Anfeng Li, Fang Wang, Mou Jiang, Yu Li, Xin Zhou, Zhong‐Xing Jiang   +5 more
wiley   +1 more source