Results 81 to 90 of about 999,147 (302)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Achieving high density and controlled microstructure by predicting hot deformation behavior of low-cost powder metallurgy Ti-5553 alloy

Journal of Materials Research and Technology
This study investigates the hot deformation behavior of sintered Ti-5553 alloy with the objective of providing a comprehensive description of its flow behavior, developing a constitutive model, and processing maps.
Krystian Zyguła, Oleksandr Lypchanskyi, Kamil Cichocki, Grzegorz Korpała, Marek Wojtaszek, Ulrich Prahl   +5 more
doaj   +1 more source

Izkovki iz magnezijevih zlitin za avtomobilsko industrijo [PDF]

, 2015
The paper presents an investigation of the effect of process variables and material condition on the forgeability of magnesium wrought alloys of the Mg-Al-Zn group.
Greger, Miroslav, Karas, Vlastimil, Madaj, Michal   +2 more
core  

Investigation on Mechanism of Microstructure Evolution during Multi-Process Hot Forming of GH4169 Superalloy Forging

Materials
Typically, in the manufacturing of GH4169 superalloy forgings, the multi-process hot forming that consists of pre-deformation, heat treatment and final deformation is required.
Ming-song Chen, Hong-Wei Cai, Yong-cheng Lin, Guan-Qiang Wang, Hong-bin Li, An Liu, Zehao Li, Shan Peng   +7 more
semanticscholar   +1 more source

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Pembuatan Material Dual Phase dari Komposisi Kimia Hasil Peleburan antara Scaling Baja dan Besi Laterit Kadar Ni Rendah yang Dipadu dengan Unsur Sic [PDF]

, 2016
Pada percobaan penelitian ini telah dilakukan proses pembuatan material dual phase, di mana materialnya diperoleh dari hasil peleburan antara scaling baja dan besi laterit kadar Ni rendah yang dipadu dengan unsur SiC.
Malau, D. P. (Daniel), Saefudin, S. (Saefudin)   +1 more
core   +1 more source

Dual‐Stage Heat Treatment for Enhanced Hydrogen Storage Properties of Mg−Ni−Y Alloys

Rare Metals, EarlyView.
ABSTRACT Mg−Ni−Y alloy is considered to be one of the most promising hydrogen storage materials, but its high dehydrogenation energy barrier hinders its practical application. A dual‐stage heat treatment (490°C × 4 h + 550°C × 4 h) is applied to optimize the microstructure and hydrogen storage performance of a vacuum‐melted Mg94Ni3Y3 alloy.
You Lv, Qiang Yang, Jixing Zhu, Dongyue Zhao, Junyuan Fan, Valery Konstantinovich Sheleg, Xin Qiu   +6 more
wiley   +1 more source

Comparing the efficiency of flowsheets for hot die forging on crank presses

MATEC Web of Conferences, 2018
The process of manufacturing a part as a semi-finished product (a forging) using hot die forging with further machining can be performed on various types of press forging equipment following several flowsheet variants.
Telegin Igor, Shumilova Tatyana
doaj   +1 more source

Neural Network Multiobjective Optimization of Hot Forging

Procedia CIRP, 2018
Abstract Hot Forging optimization depends on several factors, known with uncertainty: die pre-heating, geometry, tempering, workpiece temperature and shape, lubricant. There are also several objectives: quality, energy consumption and tool life. Global optimization methods require a numerous process evaluations to reach the optimum.
Doriana M. D’Addona, D. Antonelli
openaire   +4 more sources

Characterising the impact of surface integrity on the fatigue behaviour of a shot-peened connecting rod [PDF]

, 2014
The present study focuses on analysing and modelling the influence on fatigue behaviour of the surface of a hot-forged C70 connecting rod which undergoes a shot-blasting treatment.
GERIN, Benjamin, MOREL, Franck, PESSARD, Etienne, VERDU, Catherine   +3 more
core   +2 more sources