Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
Hot topics in Cellular Neuropathology IV-targeting neurological diseases by gene therapy approaches. [PDF]
Hermann DM.
europepmc +1 more source
Programmable Sequential 4D Actuation in Multistable Kirigami Metamaterials
This study presents a modular kirigami metamaterial framework enabling programmable multistability and sequential 4D actuation. By coupling geometry‐controlled multistability with material‐dependent recovery kinetics, spatiotemporal deformation can be precisely programmed.
Eui‐Hyun Kim +3 more
wiley +1 more source
Effectiveness and feasibility of residential passive heat adaptation interventions on reducing indoor temperature in low-income communities in Africa: a systematic review. [PDF]
Nakanjako R +8 more
europepmc +1 more source
Water‐soluble amine‐functionalized polyhedral oligomeric silsesquioxane promotes concurrent latex coalescence and crosslinking, allowing epoxy‐functional particles to form continuous films without added volatile coalescing agents. The resulting multiscale‐reinforced waterborne coatings combine high strength, toughness, optical transparency, scratch ...
Chao Wang +7 more
wiley +1 more source
Character level attention siamese networks for Chinese handwriting comparison. [PDF]
Zhu L, Tang L, Mao H.
europepmc +1 more source
This review presents the research advances of adaptive conductive systems from the perspective of materials, circuits, systems, and applications. Deformable conductors consist of substrates/matrices and conductive materials, structural design of circuit interconnections, fabrication of circuit interconnections, as well as intelligent systems ...
Yufei Lu +7 more
wiley +1 more source
Interpopulation Variation in Egg Mortality in Response to Hot and Dry Conditions in North American Populations of the Invasive Tiger Mosquito, <i>Aedes albopictus</i>. [PDF]
Westby KM +4 more
europepmc +1 more source
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu +11 more
wiley +1 more source
Thematic characteristics and research hot-spots of China's healthy aging policy: topic modeling study. [PDF]
Han J +7 more
europepmc +1 more source

