An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi +5 more
wiley +1 more source
OptiMo-LDLr: An Integrated In Silico Model with Enhanced Predictive Power for LDL Receptor Variants, Unraveling Hot Spot Pathogenic Residues. [PDF]
Larrea-Sebal A +12 more
europepmc +1 more source
Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi +13 more
wiley +1 more source
Interfacial charge transfer and low‐resistance interphase formation between PEO‐based polymer and Li10GeP2S12 solid electrolytes are investigated using multi‐electrode impedance spectroscopy and advanced analytical techniques such as XPS and ToF‐SIMS.
Ujjawal Sigar +6 more
wiley +1 more source
Structural screening and molecular simulation identify potential ligands against the K700E hot spot variant and functional pockets of SF3B1 to modulate splicing in myelodysplastic syndrome. [PDF]
García R, Atis M, Cox A, Koduru P.
europepmc +1 more source
A novel PIK3CA hot-spot mutation in breast cancer patients detected by HRM-COLD-PCR analysis. [PDF]
Debouki-Joudi S +8 more
europepmc +1 more source
Target-induced hot spot construction for sensitive and selective surface-enhanced Raman scattering detection of matrix metalloproteinase MMP-9. [PDF]
Jin H, Liu T, Sun D.
europepmc +1 more source
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Tuning Temperature and Size of Hot Spots and Hot‐Spot Arrays
Small, 2010AbstractBy using scanning thermal microscopy, it is shown that nanoscale constrictions in metallic microwires deposited on an oxidized silicon substrate can be tuned in terms of temperature and confinement size. High‐resolution temperature maps indeed show that submicrometer hot spots and hot‐spot arrays are obtained when the SiO2 layer thickness ...
Elika, Saïdi +7 more
openaire +2 more sources
In a recent paper. Pfister and Norton[4] brought to our attention the potential degradation in performance of multi-stage interconnection networks in the presence of nonuniform traffic patterns. More specifically, they studied the effect of a single hot spot - a location that is accessed more frequently - in an ...
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