Results 31 to 40 of about 857,013 (301)

Koalas in space and time: Lessons from 20 years of vehicle-strike trends and hot spots in South East Queensland

, 2023
The localized clustering of wildlife vehicle-strike in space and time, often called ‘hot spots’, are commonly used to guide placement of road mitigation installations.
Dexter, CE, Appleby, RG, Scott, J, Kerlin, DH, Blacker, ARF, Jones, DN   +5 more
core   +1 more source

Computationally identifying hot spots in protein-DNA binding interfaces using an ensemble approach

BMC Bioinformatics, 2020
Background Protein-DNA interaction governs a large number of cellular processes, and it can be altered by a small fraction of interface residues, i.e., the so-called hot spots, which account for most of the interface binding free energy.
Yuliang Pan, Shuigeng Zhou, Jihong Guan
doaj   +1 more source

Interobserver Variability of Ki-67 Measurement in Breast Cancer [PDF]

Journal of Pathology and Translational Medicine, 2016
Background: As measurement of Ki-67 proliferation index is an important part of breast cancer diagnostics, we conducted a multicenter study to examine the degree of concordance in Ki-67 counting and to find factors that lead to its variability.
Yul Ri Chung, Min Hye Jang, So Yeon Park, Gyungyub Gong, Woo-Hee Jung,   +5 more
doaj   +1 more source

Prediction of tuberculosis clusters in the riverine municipalities of the Brazilian Amazon with machine learning [PDF]

Revista Brasileira de Epidemiologia
Objective: Tuberculosis (TB) is the second most deadly infectious disease globally, posing a significant burden in Brazil and its Amazonian region. This study focused on the “riverine municipalities” and hypothesizes the presence of TB clusters in the ...
Luis Silva, Luise Gomes da Motta, Lynn Eberly   +2 more
doaj   +1 more source

Climate Change and the Pattern of the Hot Spots of War in Ancient China

Atmosphere, 2020
Quantitative research on climate change and war hot spots throughout history is lacking. In this study, the spatial distribution and dynamic process of war hot spots under different climatic phases in imperial China (1–1911 CE) are revealed using ...
Shengda Zhang, David Dian Zhang, Jinbao Li   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Identifying Conservation Priority Areas of Hydrological Ecosystem Service Using Hot and Cold Spot Analysis at Watershed Scale

Remote Sensing
Hydrological Ecosystem Services (HES) are crucial components of environmental sustainability and provide indispensable benefits. The present study identifies critical hot and cold spots areas of HES in the Aglar watershed of the Indian Himalayan Region ...
Srishti Gwal, Dipaka Ranjan Sena, Prashant K. Srivastava, Sanjeev K. Srivastava   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Antisocial and prosocial activities at crime hot spots: Rethinking conventional paradigms [PDF]

Numerous studies emphasise that crime hot spots are antisocial activity nodes where disorder and crime are prevalent. However, researchers to date have not considered prosocial activities at crime hot spots, and how such activities compare to those at ...
Weisburd, David, Kuen, Kiseong, Uding, Clair, Ready, Justin   +3 more
core   +1 more source