This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou +19 more
wiley +1 more source
Spatial overlap of sea ice-associated predators and prey in western Hudson Bay. [PDF]
Warret Rodrigues C +4 more
europepmc +1 more source
County-Level Hotspot Identification and Spatial Regression Analysis of Health Loss from Kashin–Beck Disease — China, 2019 and 2023 [PDF]
Ying Liu +11 more
openalex +1 more source
Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems
Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li +6 more
wiley +1 more source
Revisiting Ki-67 Assessment in Canine Mast Cell Tumours: From Manual Hotspot to Automated Global Analysis. [PDF]
Scalco R +5 more
europepmc +1 more source
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas +6 more
wiley +1 more source
Smoothie: efficient inference and integration of spatial co-expression networks from denoised spatial transcriptomics data. [PDF]
Holdener C, De Vlaminck I.
europepmc +1 more source
Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu +15 more
wiley +1 more source
Analytical and clinical validation of a novel CE-IVD kit for <i>PIK3CA</i> hotspot mutations in liquid biopsy samples. [PDF]
Stergiopoulou D +7 more
europepmc +1 more source

