Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley +1 more source
Privy by the Bay: Emerging hotspot analysis of 311 reports of human/animal waste near San Francisco Pit Stop locations, 2009-2022. [PDF]
Bogulski CA, Watson WP, Young SG.
europepmc +1 more source
Research Trends and Hotspot Analysis of Conjunctival Bacteria Based on CiteSpace Software. [PDF]
Wang Z, Huang C, Li X.
europepmc +1 more source
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang +9 more
wiley +1 more source
Detecting the Seasonal and Spatial Patterns of COVID-19 Hospitalization and Deaths in Iran: Insights from a Spatiotemporal and Hotspot Analysis. [PDF]
Mounesan L +10 more
europepmc +1 more source
Global dissemination of tmexCD‐toprJ across bacterial hosts and ecological niches is accompanied by its convergence with blaKPC, blaNDM, and mcr on mobile plasmids. Recombination and acquisition of resistance modules generate distinct multidrug resistant plasmid architectures, facilitating the emergence and spread of high‐risk bacterial populations ...
Kaiwen Song +9 more
wiley +1 more source
Hotspot Analysis of Rumen Microbiota and Methane Mitigation in Ruminants: A Bibliometric Analysis from 1998 to 2023. [PDF]
Zheng X +5 more
europepmc +1 more source
A nuclear‐pore‐inspired nested dual‐loop architecture redistributes electromagnetic energy through coupled transport, confinement, and dissipation pathways. Integrated with Co/Fe3O4 dual‐magnetic composites and topology optimization, the 11‐mm‐thick absorber delivers continuous 2–40 GHz attenuation, raises finite‐band structural utilization to 82%, and
Shaokang Liu +6 more
wiley +1 more source
Research progress and hotspot analysis of type B aortic dissection: a bibliometric analysis from 2004 to 2023. [PDF]
Zhao ZY +4 more
europepmc +1 more source
Mesoporous‐Shell Monolayer Plasmonic Architecture Enables Quantitative and Decision‐Guided SERS
Mesoporous‐shell‐regulated molecular transport combined with monolayer hotspot determinism transforms surface‐enhanced Raman spectroscopy (SERS) from ultrasensitive detection into quantitative and decision‐guided molecular sensing. ABSTRACT Quantitative surface‐enhanced Raman spectroscopy (SERS) has long been impeded by stochastic hotspot formation ...
Guangyao Huang +9 more
wiley +1 more source

