Results 81 to 90 of about 58,377 (247)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

open access: yesAdvanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li   +9 more
wiley   +1 more source

Spatial and Temporal Analysis of Road Traffic Accidents in Major Californian Cities Using a Geographic Information System

open access: yesISPRS International Journal of Geo-Information
Road traffic accidents have increased globally, which has led to significant challenges to urban safety and public health. This concerning trend is also evident in California, where major cities have seen a rise in accidents.
Tariq Alsahfi
doaj   +1 more source

Pitch and Flat Roof Factors’ Association with Spatiotemporal Patterns of Dengue Disease Analysed Using Pan-Sharpened Worldview 2 Imagery

open access: yesISPRS International Journal of Geo-Information, 2015
Dengue disease incidence is related with the construction of a house roof, which is an Aedes mosquito habitat. This study was conducted to classify pitch roof (PR) and flat roof (FR) surfaces using pan-sharpened Worldview 2 to identify dengue disease ...
Fedri Ruluwedrata Rinawan   +6 more
doaj   +1 more source

A system for monitoring NO2 emissions from biomass burning by using GOME and ATSR-2 data [PDF]

open access: yes, 2002
In this paper, we propose a system for monitoring abnormal NO2 emissions in troposphere by using remote-sensing sensors. In particular, the system aims at estimating the amount of NO2 resulting from biomass burning by exploiting the synergies between the
Bruzzone, Lorenzo   +4 more
core  

Emerging Device Applications From Strong Light–Matter Interactions in 2D Materials

open access: yesAdvanced Science, EarlyView.
Two‐dimensional semiconductors enable extremely compact optoelectronic devices such as solar cells, sensors, LEDs, and lasers. Their strong light–matter interactions allow efficient light emission, detection, and energy conversion. This review article discusses the recent progress in integrating these materials with optical cavities and nanostructures ...
Janani Archana K   +7 more
wiley   +1 more source

Automated Analysis of Wildlife-Vehicle Conflict Hotspots Using Carcass and Collision Data [PDF]

open access: yes, 2020
Wildlife-vehicle conflict (WVC) occurs when traffic coincides with a place where animals decide to cross the surface of a roadway. State departments of transportation have a consistent need to understand rates and locations of WVC but inconsistent access
Shilling, Fraser
core  

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

open access: yesAdvanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo   +5 more
wiley   +1 more source

Spatial and temporal variation and hotspot detection of kala-azar disease in Vaishali district (Bihar), India

open access: yesBMC Infectious Diseases, 2013
Background An improved understanding in transmission variation of kala-azar is fundamental to conduct surveillance and implementing disease prevention strategies.
Bhunia Gouri Sankar   +4 more
doaj   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

open access: yesAdvanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély   +5 more
wiley   +1 more source

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