Results 171 to 180 of about 193,140 (286)

On the origin of PRDM9-guided recombination hotspots. [PDF]

Proc Natl Acad Sci U S A
Úbeda F, Bürger R, Fyon F.
europepmc   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

Characterizing spatiotemporal spread of infectious diseases using ellipse-shaped transmission hotspots: application to dengue virus outbreaks. [PDF]

Int J Health Geogr
Lin PS, Chen CH, Liu WL, Wen TH, Lu YC, Chen LW, Yuan HY, Kung YH.   +7 more
europepmc   +1 more source

Atomistic Kinetics of Dislocation‐Mediated Grain Growth in Monolayer MoS2

Advanced Science, EarlyView.
Atomic‐resolution in‐situ heating microscopy directly visualizes dislocation‐mediated grain boundary migration and grain growth in monolayer MoS2. Mobile grain boundaries migrate through collective motion of Mo 5|7 dislocations, whereas S 5|7 defects remain largely immobile.
Chang‐Won Choi, Min‐Yeong Choi, Tao Du, Jinho Rhee, Seokho Moon, Yeon‐Seo Nam, Xiaoyan Lu, Jong Kyu Kim, Jungwon Park, Moon‐Ho Jo, Cheol‐Joo Kim, Si‐Young Choi   +11 more
wiley   +1 more source

Mapping Meiotic Recombination DNA Double-Strand Breaks (DSBs) Hotspots -Methodological Advances and Challenges. [PDF]

Adv Genet (Hoboken)
Bao J.
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Redesign of energetically frustrated regions rescues function in defective T4 clamp loaders. [PDF]

Mol Biol Evol
Nimkar S, Nguyen T, Karandur D, Subramanian S, O'Donnell ME, Kuriyan J.   +5 more
europepmc   +1 more source

Targeting the CRYAB/β‐Catenin Axis with an MMP‐9‐Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation

Advanced Science, EarlyView.
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen, Danni Yang, Songying Pi, Yuhan Liu, Hongbin Huang, Feile Ye, Yuhong Lin, Zhongzhen Su, Yongquan Huang   +8 more
wiley   +1 more source

Correction: Multimodal sequencing identifies synergistic mechanisms driving resistance to neoadjuvant nivolumab treatment in hepatocellular carcinoma. [PDF]

Mol Cancer
Zeng F, Guo J, Zeng Z, Zhang VX, Tsui YM, Li PM, Husain A, Zhang Q, Lee JM, Cheung TT, Ho DW, Ng IO.   +11 more
europepmc   +1 more source

Amphibious Movement of Microrobots Inspired by Water Spiders

Advanced Science, EarlyView.
Inspired by the water strider, a novel microrobot is designed to maintain amphibious mobility in complex environments. It retains the ability to traverse the air‐liquid interface and perform directional movement within sophisticated, multifaceted environments, including complex gastric wall structures, with precise controllability.
Xiao Hu, Run Ouyang, Zhuhao Shi, Wanqiong Tao, Zuchao Zhu, Peifeng Lin, Jianzhong Lin, Luca Brandt   +7 more
wiley   +1 more source