Results 231 to 240 of about 1,989,550 (292)

Neuroprotective effects of Interleukin-1 receptor antagonism after cardiac arrest: an experimental rat study. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Arslan B, Yalınkılıç FA, Erseçkin A, Beger B, Acar B, Batu U, Oğuz MM, Yalınkılıç A, Beger O, Erdem MZ, Demir H.   +10 more
europepmc   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Precision targeting of <i>CCNE1</i>-amplified tumors-lessons from BLU-222 and beyond. [PDF]

Transl Cancer Res
Rantanen F, Ungureanu D.
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Metabolomic signatures prior to in-hospital cardiac arrest: insights into potential therapeutic targets. [PDF]

Sci Rep
Lazzarin T, Nunes JS, Ballarin RS, Azevedo PS, Pereira FWL, de Paiva SAR, Tanni SE, Zornoff L, Garrett R, Jones D, Alves MA, Minicucci MF.   +11 more
europepmc   +1 more source

DISADVANTAGES OF THE APPLICATION OF THE HOUSE ARREST TO UNDERAGE SUSPECT

Law Journal of Donbass, 2018
openaire   +1 more source

A modified Sequential Intercept Model for people living with dementia to prevent interactions with the criminal legal system. [PDF]

Gerontologist
Morgado LM, Tyler AM, Karunungan KL, Helmly V, Arias JJ.   +4 more
europepmc   +1 more source

Molecular and Cell Biological Characterization of Patient-Derived Head and Neck Squamous Carcinoma Cell Lines. [PDF]

Cancer Sci
Ito K, Ishida N, Ito S, Shindo N, Souma S, Mochizuki M, Fujimori H, Tamai K, Imai T, Yamazaki T, Yamaguchi K, Sasaki K, Miyakura Y, Murakami S, Unno Y, Asano N, Asada Y, Yasuda J.   +17 more
europepmc   +1 more source

FoCUS on Lazarus: autoresuscitation confirmed by focused cardiac ultrasound. [PDF]

Resusc Plus
Bianchi C, Maudet L, Schneider A, Garcia E, Pasquier M.   +4 more
europepmc   +1 more source