Results 41 to 50 of about 2,054,613 (335)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Dados: Revista de Ciências Sociais, 2006 The article challenges the contention that individual amendments are crucial for a system of exchanging favors with the Administration by members of Congress interested in distributive policies as a way of guaranteeing their reelection.
Fernando Limongi +2 more
doaj +1 more source
Machine learning models predicting undertriage in telephone triage
Annals of Medicine, 2022 Background Undertriaged patients have worse outcomes than appropriately triaged patients. Machine learning provides better triage prediction than conventional triage in emergency departments, but no machine learning-based undertriage prediction models ...
Ryota Inokuchi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Jurnal Pariwisata Pesona, 2019 Everyone has social capital. Social capitals own by founding community of tourist locations and tourists. This study aims to prove the influence of social capital that is owned by each individual who then encourages them to choose House of Sampoerna as ...
Asnurul Novia Narendra +2 more
doaj +1 more source
BMC Emergency Medicine, 2021 Background Prehospital telephone triage stratifies patients into five categories, “need immediate hospital visit by ambulance,” “need to visit a hospital within 1 hour,” “need to visit a hospital within 6 hours,” “need to visit a hospital within 24 hours,
Ryota Inokuchi +5 more
doaj +1 more source
Equipotential Space in Housing as a Strategy for Adaptability
Materia Arquitectura, 2021 Architecture must provide answers, in the domestic realm, to the constant and vertiginous change in contemporary society’s needs and lifestyles. For this reason, we propose to examine the concept of 'adaptability' in housing based on the study of a ...
José Luis Bezos Alonso
doaj +1 more source