Results 71 to 80 of about 2,054,613 (335)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

From linear to nonlinear models: Responsiveness of house prices to shocks from macroeconomic indicators in Kenya

Scientific African
Previous studies have concluded that models that account for nonlinear relationships outperform their linear counterparts. However, while this is evident in advanced economies, the same cannot be inferred in Sub-Saharan Africa.
Benjamin Kwakye, Alexander Sasu, Stephen Ameyaw, Frank Gyamfi-Yeboah   +3 more
doaj   +1 more source

Authoring a Web-enhanced interface for a new language-learning environment

Research in Learning Technology, 2000
Computer-based applications in second language teaching have now been used for a protracted period of time, evolving from a deductive approach relying on grammatical progression to inductive methods and, more recently, exploratory interaction better ...
Dominique Hémard, Steve Cushion
doaj   +1 more source

Cloud Migration: A Case Study of Migrating an Enterprise IT System to IaaS

, 2010
This case study illustrates the potential benefits and risks associated with the migration of an IT system in the oil & gas industry from an in-house data center to Amazon EC2 from a broad variety of stakeholder perspectives across the enterprise, thus ...
Greenwood, David, Khajeh-Hosseini, Ali, Sommerville, Ian   +2 more
core   +3 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Patient house calls in Attica and Thessaloniki, Greece (2005-2015): a model for out-of-hospital multispecialty emergency medicine

BMC Health Services Research, 2018
Background The SOS-doctors are a network of physicians who perform house-call visits in the areas of Attica and Thessaloniki, Greece. Methods Patients requesting medical services by the SOS doctors during the period 1/1/2005 – 31/12/2015 were eligible ...
George Theocharis, Spyridon G. Barbas, Theodore Spiropoulos, Petroula E. Stamouli, Dimitrios N. Perdikis, Matthew E. Falagas   +5 more
doaj   +1 more source

Labour Market Segmentation Revisited: A Study of the Dutch Call Centre Sector [PDF]

Employment in the call centre sector in the Netherlands, similar to the trend in other European countries, is expanding greatly. In 2001, Datamonitor (2002) estimated that 1,266 call centres were operating in the Netherlands.
Grip Andries de, Jaarsveld Danielle van, Sieben Inge   +2 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Processing Information During Regressions: An Application of the Reverse Boundary-Change Paradigm

Frontiers in Psychology, 2018
Although 10–15% of eye-movements during reading are regressions, we still know little about the information that is processed during regressive episodes.
Patrick Sturt, Nayoung Kwon
doaj   +1 more source