Results 31 to 40 of about 51,332 (222)
Transfer learning for topic labeling: Analysis of the UK House of Commons speeches 1935–2014
Research & Politics, 2021 Topic models are widely used in natural language processing, allowing researchers to estimate the underlying themes in a collection of documents. Most topic models require the additional step of attaching meaningful labels to estimated topics, a process ...
Hannah Béchara +3 more
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Politics and GovernanceParliamentary assistants (PAs) to parliamentarians are recognised as a critical part of the parliamentary machinery. Despite their relevance in supporting parliamentarians’ work, the literature has shown little interest in them or their practices.
Sebastian Ludwicki-Ziegler
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Alcohol consumption of UK members of parliament: cross-sectional survey
BMJ Open, 2020 Objectives This study examined the prevalence of risky drinking by members of parliament (MPs), as well as the relationship between risky drinking and age, years spent as an MP, working outside parliament, awareness of the Parliamentary Health and ...
Jayati Das-Munshi +5 more
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Applied Network Science, 2021 The British party system is known for its discipline and cohesion, but it remains wedged on one issue: European integration. We offer a methodology using social network analysis that considers the individual interactions of MPs in the voting process ...
Carla Intal, Taha Yasseri
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
British Women and their obtainment of Membership in the House of Commons (1918-1927)
آداب الكوفةThe Qualification of Women Act, which granted women the right to membership in the House of Commons and to participate in its debates, is a positive step that complements a law previously approved by the British government in the same year, which is the
اسراء محمد +1 more
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