Results 41 to 50 of about 166,356,720 (268)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Key Texas Senate and House water committee chairmen discuss water issues of the 85th Legislature
Texas Water Journal, 2017 Editor-in-Chief’s note: In every odd-numbered year, the Texas Legislature convenes in regular session for 140 days. With this in mind, the Texas Water Journal invited Senator Charles Perry, Chairman of the Senate Agriculture, Water & Rural Affairs ...
Sen. Charles Perry, Rep. Lyle Larson
doaj
EconomiesPopulation aging in Asia is arriving before the institutions to support it. Assessments of social protection usually treat sustainability, adequacy and fairness separately, obscuring how they trade off within one system.
Mana Luksamee-arunothai, Phubet Senbut
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Maine’s Congressional Delegation Reflections on Our Shared Ocean
Maine Policy Review, 2023 Susan M. Collins +3 more
doaj +1 more source
Cleaning OCR'd text with Regular Expressions
The Programming Historian, 2013 Optical Character Recognition (OCR)—the conversion of scanned images to machine-encoded text—has proven a godsend for historical research. This process allows texts to be searchable on one hand and more easily parsed and mined on the other. But we’ve all
Laura Turner O'Hara
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Cogent EducationThis study aims to provide a critical examination of how English as a Second Language (ESL) teachers in primary classrooms in Malaysia utilise the phonics approach when teaching reading.
Azyan Shafee +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source