Results 101 to 110 of about 2,509,546 (302)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The demand for financial services by the rural poor [PDF]

open access: yes
This policy brief summarizes lessons learned from IFPRI's multicountry program on rural finance and household food security with regard to the poors' demand for financial services. The lessons are derived from detailed household surveys conducted in nine
Sharma, Manohar, Zeller, Manfred
core  

Magnitude of Out of Pocket Health Expenditures and Associated Factors Among Civil Servants [PDF]

open access: yes, 2015
In Ethiopia, as other developing countries, public health care is provided at nominally low prices and free to those that does not afford to pay. But the health care consumer population is still to make considerable amount of out-of-pocket health ...
Gedefaw, M. (Molla)   +3 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Dihydroavenanthramide D Enhances Skin Barrier Function through Upregulation of Epidermal Tight Junction Expression

open access: yesCurrent Issues in Molecular Biology
Skin barrier dysfunction and thin epidermis are hallmarks of sensitive skin and contribute to premature aging. Avenanthramides are the primary bioactive components of colloidal oatmeal, a commonly used treatment to enhance skin barrier function.
Jiye Park   +5 more
doaj   +1 more source

Gender and poverty: how we can be misled by the unitary model of household resources – the case of Tajikistan

open access: yes, 2005
Using the 2003 Tajikistan Living Standard Survey this paper looks at the relationship between gender and poverty and show how, by modifying the equal sharing assumption of the household resources, we can easily be misled by the poverty and gender ...
Baschieri, Angela, Falkingham, Jane
core  

Household budgets and women's incomes [PDF]

open access: yes, 1980
African Studies Center Working Paper No. 28While explaining proposed studies of aspects of "household economics" to prospective informants in two different African societies, I have been advised very quickly that "Among us, a man and his wife do not ...
Guyer, Jane I.
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Biophysical characteristics of mild-dandruff scalp in association with hyperkeratinized corneocytes and the inflammatory cytokine interleukin-8: a preliminary study

open access: yesHeliyon
Dandruff is a common and persistent scalp condition involving symptoms such as skin flaking, itching, and redness. This preliminary study aimed to investigate the biophysical and physiological characteristics of dandruff to develop preventive strategies.
Jaeyoon Kim   +6 more
doaj   +1 more source

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