Results 81 to 90 of about 1,166,912 (303)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Transmission of acute infectious illness among cases of Kawasaki disease and their household members

, 2017
Background/purpose: Kawasaki disease (KD) is a disease of unknown cause and the causative agent is most likely to be infectious in nature. To investigate the household transmission pattern of infectious illness and etiology, we thus initiated a ...
Tsai, Hsing-Chen;Chang, Luan-Yin;Lu, Chun-Yi;Shao, Pei-Lan;Fan, Tsui-Yen;Cheng, Ai-Ling;Hu, Jen-Jan;Yeh, Shu-Jen;Chang, Chien-Chih;Huang, Li-Min, 呂俊毅;黃立民;張鑾英;邵蓓嵐   +1 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Survey data on household finance and consumption - research summary and policy use [PDF]

The first part of this paper provides a brief survey of the recent literature that employs survey data on household finance and consumption. Given the breadth of the topic, it focuses on issues that are particularly relevant for policy, namely i) wealth ...
The Eurosystem Household Finance and Consumption Network
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mechanisms underlying the absence of disease transmission by bed bugs

Discover Life
Bed bugs (Cimex lectularius and Cimex hemipterus) are obligate blood-feeding ectoparasites that live in close association with humans, yet they are not recognized as vectors of infectious disease.
Li Lim, Abdul Hafiz Ab Majid
doaj   +1 more source

Timed-Release Silica Microcapsules for Consistent Fragrance Release in Topical Formulations

Applied Sciences
Microcapsules are widely utilized in various applications to preserve active ingredients for prolonged durations while enabling controlled release. However, limited release of active ingredients often hampers their effectiveness in daily-use products. In
Junseok Yeom, Minseo Kang, Areum Goh, Jeonghoon Jeon, Woo Sun Shim, Nae Gyu Kang   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Super-resolution mapping reveals NAD⁺-delivering probiotic extracellular vesicles as nanotherapeutics for organelle protection and inflammation control

Journal of Nanobiotechnology
Background Lactobacillus plantarum (L. plantarum) is a probiotic bacterium with diverse health-promoting effects. Recent evidence suggests that these benefits are mediated by extracellular vesicles (EVs) secreted by the bacterium; however, the underlying
Ga-eun Go, Minjae Kang, Bo Kyoung Hwang, Sangoh Choi, Uidon Jeong, Eunyoung Moon, Sang-Hee Lee, Seongsu Kang, Nae-Gyu Kang, Yunkwan Kim, Euitaek Jeong, Doory Kim   +11 more
doaj   +1 more source