Results 201 to 210 of about 2,631,521 (295)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Household SARS-CoV-2 transmission during Omicron wave in Chiang Mai, Thailand: a prospective observational study. [PDF]

Lancet Reg Health Southeast Asia
Khamduang W, Suebtam P, Collins IJ, Sripan P, Chalom K, Hongjaisee S, Kham-Kjing N, Wangsaeng N, Inmonthian P, Pinasu A, Kohklang N, Arnal M, Spyer M, Steffens-Westerhof I, Aramrattana A, Lallemant M, Angkurawaranon C, Bruijning-Verhagen P, Ngo-Giang-Huong N.   +18 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Global patterns and determinants of household medicine storage and disposal: a systematic review and meta-analysis. [PDF]

J Pharm Policy Pract
Chit GN, Thin SM, Theeraroungchaisri A, Watcharadamrongkun S, Kittisopee T.   +4 more
europepmc   +1 more source

Association between household food insecurity and annual health care costs [PDF]

, 2015
Valerie Tarasuk, Joyce Cheng, Claire de Oliveira, Naomi Dachner, Craig Gundersen, Paul Kurdyak   +5 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

'Pagbangon at Pag-Asa' (Resurgence and Hope): A Qualitative Study of the Lived Experiences of People With Stroke and Household Carers in the Philippines. [PDF]

Health Expect
Buckingham SA, Anota E, Barba MM, Boac V, Estrada M, Faeldon L, Kent B, Leggat F, Navea RF, Ong APR, Santos NM, Teves A, Valera PM, Jones F, TULAY project team.   +14 more
europepmc   +1 more source

The influence of household farming systems on dietary diversity and caloric intake: the case of Uganda

, 2016
Vincent Linderhof, Jeffrey P. Powell, Romain Vignes, Ruerd Ruben, Linderhof, Vincent, Powell, Jeffrey, Vignes, Romain, Ruben, Ruerd   +7 more
openalex   +2 more sources

Global hidden harvest of freshwater fish revealed by household surveys [PDF]

, 2018
Etienne Fluet‐Chouinard, Simon Funge‐Smith, Peter B. McIntyre   +2 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source