pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Understanding financial risk protection in China's health system: a descriptive analysis using data from multiple national household surveys. [PDF]
BMC Public Health, 2023 Li Y, Guan H, Fu H.
europepmc +1 more source
Re-engaging with Survey Non-respondents: The BHPS, SOEP and HILDA Survey Experience [PDF]
Previous research into the correlates and determinants of non-response in longitudinal surveys has focused exclusively on why it is that respondents at one survey wave choose not to participate at future waves. This is very understandable if non-response
Mark Wooden, Nicole Watson
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Linking Representative Household Models with Household Surveys for Poverty Analysis A Comparison of Alternative Methodologies [PDF]
We compare three approaches to linking macro models with representative households and micro household income data in terms of their implications for measuring the poverty and distributional effects of poverty reduction strategies. These approaches are a
Derek Chen +2 more
core +3 more sources
Availability of data for monitoring noncommunicable disease risk factors in India
Bulletin of the World Health Organization, 2012 OBJECTIVE: To examine the availability of data measuring noncommunicable disease (NCD) risk factor indicators from household surveys conducted in India from 2000 to 2009.
Magdalena Z Raban +2 more
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Provider-mother interactions are associated with birth outcome misclassifications in household surveys: A case-control study in Guinea-Bissau. [PDF]
J Glob Health, 2023 Damerow SM +6 more
europepmc +1 more source
The mystery of South Africa's ghost workers in 1996: measurement and mismeasurement in the manufacturing census, population census and October Household Surveys [PDF]
This paper compares estimates of total manufacturing employment from South Africa's 1996 manufacturing census, the 1996 population census and the October Household Surveys from 1995, 1996 and 1997.
Martin Wittenberg
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source