Results 241 to 250 of about 1,413,704 (315)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Spatial distribution and determinants of unimproved sanitation facilities among households in Somalia: Using Somalia integrated household budget survey (SIHBS 2022). [PDF]

PLoS One
Maidhane OM, Salih O, Muse AH, Osman AO, Abdi MH, Hassan MH, Ali NM, Elmi SA.   +7 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Health and economic burden of canine rabies in Chilga district, centeral Gondar Zone, Amhara Region, Ethiopia. [PDF]

PLoS Negl Trop Dis
Engida TB, Molla AM, Molla W, Jemberu WT.   +3 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Agroecology and gender effects on rural households' food insecurity and coping mechanisms in Borena District, Amhara Region, Ethiopia. [PDF]

BMC Nutr
Worku M, Mitiku B.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Collaborative mapping: Perceived environmental risk of leptospirosis in Urban communities in Salvador, Brazil. [PDF]

PLOS Glob Public Health
Palma FAG, Ruiz Cuenca P, Khalil H, Brito PL, Reis das Virgens MN, Arouca MG, Mota Santos A, Santos de Oliveira D, Alzete Lòpez YA, Santiago DCC, Begon M, Giorgi E, Costa F, Lustosa R.   +13 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Determinants of food insecurity among smallholder farmers in North Central Nigeria: policy implications. [PDF]

Front Nutr
Ogunfolaju MO, Ahmed TA, Ebenehi O.
europepmc   +1 more source