Results 91 to 100 of about 4,048,714 (320)

Barnes Hospital Record [PDF]

, 1965
https://digitalcommons.wustl.edu/bjc_barnes_record/1217/thumbnail ...

core   +4 more sources

216 Jewish Hospital of St. Louis [PDF]

, 1963
https://digitalcommons.wustl.edu/bjc_216/1058/thumbnail ...

core   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Effects of 2 weeks lower limb immobilization and two separate rehabilitation regimens on gastrocnemius muscle protein turnover signaling and normalization genes

BMC Research Notes, 2012
Background Limb immobilization causes a rapid loss of muscle mass and strength that requires appropriate rehabilitation to ensure restoration of normal function.
Nedergaard Anders, Jespersen Jakob G, Pingel Jessica, Christensen Britt, Sroczynski Nicholas, Langberg Henning, Kjaer Michael, Schjerling Peter   +7 more
doaj   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

IJCM_354A: Mental health screening of workers of a tertiary care neuropsychiatry hospital of Delhi

Indian Journal of Community Medicine
Background: Employee mental health has a significant impact on productivity at work. People who work in healthcare environments are known to be at an increased risk of developing mental health issues.
Sarbjeet Khurana, Jagdish Sadija, Sushma Kumari, Sangeeta Gotewal, Uday Kumar Sinha, Ravinder Singh, Rajinder Kumar Dhamija   +6 more
doaj   +1 more source

Barnes Hospital Bulletin [PDF]

, 1982
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1196/thumbnail ...

core   +1 more source

An expanded multilocus sequence typing scheme for propionibacterium acnes : investigation of 'pathogenic', 'commensal' and antibiotic resistant strains [PDF]

, 2012
The Gram-positive bacterium Propionibacterium acnes is a member of the normal human skin microbiota and is associated with various infections and clinical conditions.
Barnard, E. (Emma), Cove, Jonathan, Eady, Anne, Gao, Anna, Li, Huiying, McDowell, A. (Andrew), Nagy, I. (István), Nord, Carl Erik, Patrick, Sheila, Tomida, Shuta   +9 more
core   +3 more sources

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source