Results 181 to 190 of about 4,048,714 (320)

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

British Journal of Pharmacology, EarlyView.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng, Yuanjun Tang, Xuedi Cao, Xiaotong Yu, Zhanya Huang, Yunyun Guo, Renjing Jin, Yan Wang, Yang Liu, Lixiang Xue, Yuqing Wang   +10 more
wiley   +1 more source

TPI1 and TPM4 are strong candidate RNA biomarkers for systemic sclerosis. [PDF]

Arthritis Res Ther
Chairta PP, Tomazou M, Menelaou S, Karathanasis N, Symeonidou S, Nicolaou P, Psarelis S, Christodoulou K.   +7 more
europepmc   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...
Shigetaka Komura, Satoru Kondo, Hideya Kawasaki, Shinji Watanabe, Satoshi Yamada, Hirotomo Dochi, Han Gia Nguyen, Isao Ohta, Makiko Moriyama‐Kita, Masaki Fukuyo, Kousho Wakae, Yuki Kitagawa, Harue Mizokami, Luyao Liu, Nobuyuki Hirai, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Naohiro Wakisaka, Rikinari Hanayama, Kiyoshi Misawa, Atsushi Kaneda, Tomokazu Yoshizaki   +24 more
wiley   +1 more source

ERRATUM: Hyperglycaemia-induced resistance to Docetaxel is negated by metformin: a role for IGFBP-2. [PDF]

Endocr Relat Cancer
Biernacka KM, Persad RA, Bahl A, Gillatt D, Holly JMP, Perks CM.   +5 more
europepmc   +1 more source

SOD2‐Superoxide Metabolic Axis Regulates Mitophagy and Modulates TKIs Sensitivity in Head and Neck Squamous Cell Carcinoma

Cancer Science, EarlyView.
Our findings provide compelling evidence that the SOD2‐superoxide metabolic axis functions as a mitochondrial redox checkpoint that governs mitophagy and ultimately shapes TKI sensitivity. ABSTRACT Superoxide dismutase 2 (SOD2) has been implicated in head and neck squamous cell carcinoma (HNSCC), yet its mechanistic contribution in regulating tumor ...
Wan‐Hang Zhou, Shuo‐Jin Huang, An‐Xun Wang   +2 more
wiley   +1 more source

Superior normalization using total protein for western blot analysis of human adipocytes. [PDF]

PLoS One
Westerberg LJS, Dedic B, Näslund E, Thorell A, Spalding KL.   +4 more
europepmc   +1 more source

Homozygous Loss‐of‐Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities

Clinical Genetics, EarlyView.
Biallelic SLC20A1 loss‐of‐function variant causes a previously unrecognized multisystem developmental disorder. We report the first homozygous case presenting with tetralogy of Fallot, renal agenesis, polydactyly, and growth impairment. Transcriptome analysis of patient‐derived fibroblasts suggests significant dysregulation of pathways critical for ...
Eugénie Koumakis, Céline Huber, Wendy Chung, Christine Leroy, Pauline Parisot, Regis Gaudin, Mohamad Zaidan, Valérie Cormier‐Daire, Gérard Friedlander, Yoel Hirsch   +9 more
wiley   +1 more source

The RNA-binding protein MSI2 controls blood-tumor barrier permeability via LINC00667-Mediated IRF6 mRNA decay. [PDF]

J Biol Chem
Gao R, Ruan X, Xue Y, Wang P, Wang D, E T, Liu X, Liu L.   +7 more
europepmc   +1 more source

Clinical Factors Associated With Current Relevance in Allergic Contact Dermatitis: Development of Predictive Models Based on Data From the Spanish Contact Dermatitis Register (REIDAC)

Contact Dermatitis, EarlyView.
This study has shown a moderate performance of the regression model to predict current relevance (AUC = 0.679), although modelling performance has been better for specific allergens (e.g., nickel with an AUC = 0.770). Furthermore, it has identified key predictors, including female gender, specific involved sites (hands, neck, head, legs, feet), and ...
David Pesqué, Francisco Javier Ortiz de Frutos, Francisco Navarro‐Triviño, Tatiana Sanz‐Sánchez, Violeta Zaragoza‐Ninet, Susana Córdoba‐Guijarro, Javier Miquel‐Miquel, Juan Francisco Silvestre‐Salvador, Ricardo González‐Pérez, Inmaculada Ruiz‐González, Pedro Mercader‐García, Esther Serra‐Baldrich, José Manuel Carrascosa‐Carrillo, Fátima Tous‐Romero, Mercedes Rodríguez‐Serna, María Elena Gatica‐Ortega, Carmen Paredes‐Suárez, María Antonia Pastor‐Nieto, Pablo Chicharro, Marta Andreu, Araceli Sánchez‐Gilo, José Juan Pereyra‐Rodríguez, Gemma Melé‐Ninot, Paloma Sánchez‐Pedreño Guillén, Enrique Gómez de la Fuente, Marta Elosua‐González, Fernando Gallardo, Ramon M. Pujol, Ignacio García‐Doval, Leopoldo Borrego, Miguel Ángel Descalzo, Ana M. Giménez‐Arnau   +31 more
wiley   +1 more source