Patient‐reported outcomes are an important complement to physician‐assessed clinical outcome measures in Chronic Hand Eczema. In a pooled analysis of two randomised, controlled trials, twice‐daily treatment with delgocitinib cream 20 mg/g significantly improved the health‐related quality of life of patients with moderate to severe Chronic Hand Eczema ...
Andrea Bauer +7 more
wiley +1 more source
Combining degree centrality and betweenness centrality of molecular networks can effectively pinpoint individuals at high risk of HIV transmission within the network. [PDF]
Gan W +13 more
europepmc +1 more source
Allergic contact dermatitis markedly impairs quality of life (QoL) across symptoms, functioning and emotional domains. Using DLQI, Skindex‐29 and EQ‐5D‐5L, our study demonstrates a substantial multidimensional burden and highlights the need for routine, patient‐centred QoL assessment in clinical management.
Francisco José Navarro‐Triviño +3 more
wiley +1 more source
A multiplex assay based on capillary electrophoresis to detect Mycobacterium tuberculosis complex: development and clinical validation. [PDF]
Wang Y +5 more
europepmc +1 more source
Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li +8 more
wiley +1 more source
Evaluation of Streptococcus mutans strains possessing genes encoding collagen-binding proteins in the Japanese population. [PDF]
Okuda M +7 more
europepmc +1 more source
Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells
The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li +14 more
wiley +1 more source
NSUN2 mediates intestinal stem cell expansion and colorectal tumour initiation via MAPK/ERK signalling. [PDF]
Bastem Akan A +12 more
europepmc +1 more source
Nanosilicates triggered MAP4‐dependent microtubule remodelling via the ROS/MAPK pathway, shifting microtubules into a dynamic active state, which subsequently promoted activation of the STAT3 pathway, ultimately facilitating periodontal angiogenesis.
Lingling Shang, Yuhan Hu, Shaohua Ge
wiley +1 more source
Draft genome sequences of two multidrug-resistant <i>Proteus mirabilis</i> isolates from hospital wastewater and a discharge point into Manila Bay, Philippines. [PDF]
Padon SDM +8 more
europepmc +1 more source

