Results 171 to 180 of about 10,439,716 (308)

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Family Structure, Dwelling and Household Factors, and the Mental Health of Immigrant and Canadian-Born Mothers. [PDF]

J Community Psychol
Khan T, Naeem F, Butt ZA, Cooke M.
europepmc   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

The Household as Dialysis Infrastructure : Family Caregiving, Poverty, and In-Center Hemodialysis in Delaware. [PDF]

Dela J Public Health
Kapoor A.
europepmc   +1 more source

Kansas comprehensive housing affordability strategy, October 31, 1991 [1991]

, 1991
"In compliance with the Cranston-Gonzalez National Affordable Housing Act of 1990."INTRODUCTION -- EXECUTIVE SUMMARY -- SUMMARY OF THE CHAS DEVELOPMENT PROCESS -- SECTION ONE: STATE PROFILE -- PART I: MARKET AND INVENTORY CONDITIONS -- PART 2 ...
Kansas State Housing Office
core  

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Laboratory conditions matter: social housing in male and female laboratory mice in a multicenter study approach. [PDF]

Lab Anim (NY)
Mallien AS, Munk A, Rix A, Vogt MA, Pfeiffer N, Buchecker V, Girbig R, Neunecker S, Becker L, Franz M, Baier J, Brandwein C, Bleich A, Palme R, Tolba R, Potschka H, Kießling F, Chourbaji S, Talbot SR, Gass P.   +19 more
europepmc   +1 more source

Redesigning the Single-Family House: A Critical Look Back, and a Glance Forward

The chapter develops a twofold reflection. On the one side, it critically assesses some design approaches dedicated to single-family housing that influenced the academic and professional discourse in the last five decades such as sprawl containment, the ...
M. Tattara, F. Zanfi
core  

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Overcoming arguments against tackling child poverty and inequalities: marshalling the evidence. [PDF]

BMJ Paediatr Open
Limburg M, Cronin M, Pickett KE, Taylor-Robinson D.   +3 more
europepmc   +1 more source