Results 61 to 70 of about 777,573 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The House, the Home and the Housing Question

Docomomo Journal, 2014
Housing is a central program in contemporary architectural production. Incorporating civilizing values of 19th century culture, the house arrives in the 20th century at the time notions of private space and domestic comfort come to the fore in Western Culture as values inseparable from the emergence of the family in domestic space: the home.
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Evaluation of Fire Hazard and Safety Management of Heritage Buildings in Georgetown, Penang

MATEC Web of Conferences, 2014
Fire is a subject that is always neglected and ignored as far as heritage buildings are concerned. Unlike newly-built buildings, which are required under UBBL to undergo certain fire protection system tests, people are less likely to carry out such tests
Othuman Mydin M.A., Sani N. Md, Abas N.F., Khaw Y.Y.   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Private renters’ housing experiences in lightly regulated markets: Review of qualitative research [PDF]

, 2020
It is known that the private rented sector (PRS) accommodates an increasingly diverse range of households and plays a variety of roles in the housing market (Marsh and Gibb, 2019).
Soaita, Adriana Mihaela, Munro, Moira, McKee, Kim, Soaita, Adriana M   +3 more
core  

Determining the Compressive, Flexural and Splitting Tensile Strength of Silica Fume Reinforced Lightweight Foamed Concrete

MATEC Web of Conferences, 2014
This study investigated the performance of the properties of foamed concrete in replacing volumes of cement of 10%, 15% and 20% by weight. A control unit of foamed concrete mixture made with ordinary Portland cement (OPC) and 10%, 15% and 20% silica fume
Mydin M.A.O., Sani N. Md., Mohd Yusoff M.A., Ganesan S.   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Social housing allocation, choice and neighbourhood ethnic mix in England [PDF]

, 2016
Driven by a concern about the negative side effects of ethnic concentration neighbourhoods, many European governments aim to create more ethnically and socio-economically mixed neighbourhoods.
Van Ham, Maarten, Manley, David John
core   +1 more source

A community-based health assessment among residents of affordable housing in San Francisco’s Hunters Point

Discover Public Health
We conducted a community-based participatory health assessment in San Francisco’s Hunters Point Hill neighborhood, led by a community-based affordable housing organization in partnership with academic public health researchers.
Lucia E. Calderon, Taylor Booker, Sharron Watts, David Sobel, Mitch Mankin, Amy Rich, Alison K. Cohen   +6 more
doaj   +1 more source