Results 61 to 70 of about 114,583 (260)

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Objectives and Barriers to Promoting Social Housing Policy in Urban Finland

Tidsskrift for boligforskning
According to Finnish national housing policy, social rental housing (ARA) plays a key role in providing affordable housing and combating segregation in growing urban regions, in particular in Finland’s three largest urban regions (Helsinki, Tampere and ...
Jarkko Rasinkangas, Katriina Rosengren, Hannu Ruonavaara   +2 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Housing Concept and Analysis of Housing Classification

Baltic Journal of Real Estate Economics and Construction Management, 2016
Housing is one of the most important life components giving shelter, safety and warmth, as well as providing a place to rest. There is a lack of unified definition for housing concept in Latvia.
Henilane Inita
doaj   +1 more source

Brazilian National Housing Policy

Politikon, 2014
Regarding the National Housing Policy in Brazil, this paper aims to identify how institutional capacities vary into municipalities, and if this variation is related to housing deficit rates.
Renata Mendes Bezerra
doaj   +1 more source

Understanding Egg Price Volatility and Policy Implications in the U.S. With Machine Learning

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Eggs are an inexpensive and sustainable source of proteins, but volatility in the U.S. egg prices has intensified in recent years, raising concerns over food affordability and market stability. This study examines the drivers of U.S. egg price dynamics over 2004–2025 using a two‐stage framework that combines LASSO‐based variable selection with
Xuemei Zhao, Simon Meister, Lucie Maruejols, Xiaohua Yu   +3 more
wiley   +1 more source

Housing Policy as Tool of Space Development of Regions

Вестник Российского экономического университета имени Г. В. Плеханова
The article tries to develop an adaptive scenario for housing policy implementation in different types of Russian regions as a basis of the research the authors took the concept of grading factors that impact space development in accordance with current ...
M. I. Buzulutsky
doaj   +1 more source

Assessing Household Welfare in Response to Rising Food Prices in The Gambia

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study examines how rising food prices affected household welfare in The Gambia using nationally representative data from the 2015/16 Integrated Household Survey (IHS‐3). The analysis reflects household consumption behavior and market conditions prevailing during that period and provides a structural benchmark for understanding ...
Roger Vorsah, Obed Quaicoe, Fafanyo Asiseh, John N. Ng'ombe   +3 more
wiley   +1 more source

Тhe policy of Harry Truman’s administrations on solving the housing problem in the USA in 1945-1952

Американська історія і політика, 2017
The article provides a detailed analysis of the policy of Harry Truman’s Administrations on solving the housing problem in the USA in 1945-1952. The preconditions and causes of the emergence of a deep housing problem in the USA at the end of the World ...
Mariia Kravchenko
doaj   +1 more source