Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Metropolitan Growth Policies and New Housing Supply: Evidence from Australia\u27s Capital Cities [PDF]
, 2011 This paper empirically examines the relationship between house price change, metropolitan growth policies, and new housing supply in Australia\u27s five major capital cities.
McLaughlin, Ralph B
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
The role of housing price mediation in transferring the effect of heterogeneous behavior of investors in the housing sector on Iran's economic growth [PDF]
اقتصاد باثباتThe purpose of this paper is to analyze the effect of the heterogeneous behavior of investors in the housing sector on housing prices and subsequently on Iran's economic growth during the period 2001:3 to 2020:3.
Aliakbar Gholizadeh, Shahla Samadipour
doaj +1 more source
How Real Estate Shocks Affect Manufacturing Value Chain Upgrading: Evidence from China
Buildings, 2022 Contrary to the conventional viewpoint that “high housing price promotes industrial upgrading”, this study finds that increasingly high housing prices are a pivotal factor that obstructs industrial value chain upgrading.
Yanzhao Yin +3 more
doaj +1 more source
Frictionless house-price momentum
Journal of Economic Dynamics and ControlzbMATH Open Web Interface contents unavailable due to conflicting licenses.
Patrick Fève, Alban Moura
openaire +6 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
ECONOMIC DETERMINANTS OF HOUSING INVESTMENT IN IRAN [PDF]
پژوهشهای اقتصادی, 2011 An autoregressive distributed lag (ARDL), approach to cointegration analysis is used to study the short- and long-run determinants of housing investment in Iran over the period of 1375:3-1385:4.
Jafar Ghaderi +2 more
doaj