Results 61 to 70 of about 769,545 (263)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Investment Market of Non-Corporate Developers in Poland – Survey Analysis

open access: yesReal Estate Management and Valuation
The paper presents an analysis of the private-sector developers’ investment market in Poland focusing on its spatial effects. Initial observations showed an increase in the share of small developers in the Polish market.
Kleszcz Justyna   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

New housing supply: what do we know and how can we learn more? [PDF]

open access: yes
This paper reviews the literature on new housing supply. The paper starts by summarizing the results of the empirical studies on housing supply, showing that overall these studies reject the hypothesis of a perfectly elastic housing supply and reveal ...
Cesaltina Pacheco Pires   +1 more
core  

The behaviour of regional housing markets and construction: implications for modelling sub-regional housing supply [PDF]

open access: yes, 2010
Recent advances in modelling housing investment in the UK and the United States have centred on estimation of price elasticity of supply and on estimating key relationships in the behaviour of housing prices and construction output at regional level. Yet,
Leishman, C.
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Effects of Affordable Housing Land Supply on Housing Prices: Evidence from 284 Cities in China

open access: yesLand
The policy objectives of affordable housing programs in China are two-fold: on the one hand, they are designed to assist low- and moderate-income families and reduce inequality; on the other hand, they are intended to lower commodity housing prices ...
Xue Han, Changchun Feng
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

China’s New Housing Security Model: Evaluation of the Job–Housing Balance in Affordable Rental Housing, Shanghai

open access: yesLand
The Chinese government’s recent low-income housing scheme aims to tackle housing challenges faced by the urban floating population. A notable shift in this initiative is the focus on the job–housing balance.
Peihong Wang, Kerun Li, Wenbing Zhang
doaj   +1 more source

Spatial Patterns of Affordable Housing Needs in Portugal [PDF]

open access: yesJournal of Economic and Social Development (Varaždin), 2020
Ensuring the provision of affordable housing is an important and challenging role of planning practice, both at macro and micro level. The adequacy of housing supply to the population’s (present and future) needs, preferences and income is particularly ...
MARQUES JOÃO Lourenço
doaj  

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