Results 51 to 60 of about 99,689 (258)

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Learning from Seoul: Public Rental Housing Development in South Korea and Its Implications for China’s Affordable Housing System Toward “Better Housing”

Buildings
In the context of China’s vigorous promotion of “better housing” construction, transforming affordable housing into “better housing” has become an important practical task. Since the 1960s, when the public housing system was standardized, South Korea has
Xue-Rui Wang, Li-Ping Yang, Hong-Xia Yang, Byung-Kweon Jun   +3 more
doaj   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Social Support, Depression and Self-Reported Physical Health in Persons Waiting for Access to Subsidized Housing

SAGE Open
Housing is a pervasive determinant of physical and mental health. Studies indicate the importance of social support to the mental and physical health of individuals who are unhoused; however, to date, little is known about this relationship in persons ...
Julia Woodhall-Melnik, Allyson Lamont, Emily Nombro, James R. Dunn, Daniel D. J. Dutton   +4 more
doaj   +1 more source

Housing and Homelessness in Australia: The Case of Marginalised Women Leaving Prison in New South Wales (NSW)

International Journal for Crime, Justice and Social Democracy
Finding safe, secure, and ongoing housing is critical for women leaving prison and is central to rebuilding their lives and supporting desistance.
Gabrielle Drake, Lynne Kilvington-Dowd, Rimple Mehta, Teddy Nagaddya, Ayah Abubasheer, Frances Drake, Gloria Larman, Maggie Hall, Robyn North   +8 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Housing affordability, cost-of-living and NHS workforce retention in a high-cost region of England: A multiphase study

SSM - Health Systems
Rising living costs in high-cost areas of England are causing financial strain for NHS staff, particularly those in lower pay bands. Housing affordability has become a key issue for workforce retention and poses risks to the stability of healthcare ...
Dillon Newton, Mariam Zarjoo, Philip Brown, Tom Simcock, Joanne Garside, John Stephenson, Sara Eastburn, Charlene Pressley, Ed Ferrari, David Leather, Tony Gore   +10 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source