Results 121 to 130 of about 189 (150)

Occurrence, spatial and temporal distribution, sources and ecological risk assessment of halogenated polycyclic aromatic hydrocarbons (HPAHs) in sediments of the East China Sea

Environmental Pollution
Halogenated polycyclic aromatic hydrocarbons (HPAHs) in marine environment have attracted increasing attention due to their persistence, bioaccumulation potential, and ecological toxicity. However, systematic investigations on their contamination levels, compositional distribution, and source apportionment in the surface sediments of the East China Sea
Gui-Peng Yang
exaly   +3 more sources

Current and Future Trends of Low and High Molecular Weight Polycyclic Aromatic Hydrocarbons in Surface Water and Sediments of China: Insights from Their Long-Term Relationships between Concentrations and Emissions

Environmental Science & Technology, 2022
In this study, we analyzed the temporal trend of polycyclic aromatic hydrocarbons (PAHs) in China using data reported over the past 20 years. We found that the total concentrations of low molecular weight PAHs (CΣLPAHs) in surface water and sediments ...
Xiaolei Qu, Daohui Lin, Kun Yang
exaly   +2 more sources

Cumulative health risk assessment of halogenated and parent polycyclic aromatic hydrocarbons associated with particulate matters in urban air

Ecotoxicology and Environmental Safety, 2015
Halogenated polycyclic aromatic hydrocarbons (HPAHs) have been reported to occur widely in urban air. Nevertheless, knowledge about the human health risk associated with inhalation exposure to HPAHs is scarce so far.
Jian-Lin Sun, Xin Jing
exaly   +2 more sources

Parent and Halogenated Polycyclic Aromatic Hydrocarbons in Seafood from South China and Implications for Human Exposure

Journal of Agricultural and Food Chemistry, 2013
This work extends previous studies on the occurrence of persistent halogenated compounds in consumer seafood from South China. Residual levels of 16 U.S.
Hong-Gang Ni, Jian-Yang Guo
exaly   +2 more sources

The G46S-hPAH mutant protein: A model to study the rescue of aggregation-prone PKU mutations by chaperones

Molecular Genetics and Metabolism, 2011
Phenylketonuria (PKU), the most common inborn error of metabolism, is caused by dysfunction of the liver enzyme phenylalanine hydroxylase (PAH), with more than 550 PAH gene mutations identified to date. A large number of these mutations result in mutant forms of the enzyme displaying reduced stability, increased propensity to aggregate, and accelerated
João, Leandro, Jaakko, Saraste, Paula, Leandro, Torgeir, Flatmark   +3 more
openaire   +2 more sources

Abstract 4477: pH-responsive PEG-HPAH micelles for drug delivery and their potential in cancer therapy

Cancer Research, 2014
Abstract pH-responsive hyperbranched polymers have attracted much attention due to their unique properties for tumor-targeted drug delivery. In this study, we describe a pH-responsive drug carrier, poly (ethylene glycol) (PEG)-hyperbranched polyacylhydrazone (HPAH), which can form nanoscale micelles to be used as anti-cancer drug ...
Qin Xu, Jingshuang Yu, Bangshang Zhu
openaire   +1 more source

Crystal structure of the flavin reductase of Acinetobacter baumannii p-hydroxyphenylacetate 3-hydroxylase (HPAH) and identification of amino acid residues underlying its regulation by aromatic ligands

Archives of Biochemistry and Biophysics, 2018
The first step in the degradation of p-hydroxyphenylacetic acid (HPA) is catalyzed by the two-component enzyme p-hydroxyphenylacetate 3-hydroxylase (HPAH). The two components of Acinetobacter baumannii HPAH are known as C1 and C2, respectively. C1 is a flavin reductase that uses NADH to generate reduced flavin mononucleotide (FMNH-), which is used by ...
Anan, Yuenyao, Nopphon, Petchyam, Nuntaporn, Kamonsutthipaijit, Pimchai, Chaiyen, Danaya, Pakotiprapha   +4 more
openaire   +2 more sources

Mild hPAH mutations

2005
FCT: project POCTI/MGI/40844/2001 and SFRH/BD/10.807 ...
Nascimento, C, Tavares de Almeida, I, Leandro, P   +2 more
openaire   +1 more source

HPAH mice's lung scRNA-seq

The single-cell RNA sequencing data of lung tissues of male C57BL/6J mice raised in normoxic condition or in hypoxic condition for 3, 7, 14, 21 or 28 days.
openaire   +1 more source

Alternative Splicing Of BMPR2 Modifies Heritable Pulmonary Arterial Hypertension (HPAH) Penetrance

C108. GENETICS AND FUNCTIONAL GENOMICS OF PULMONARY VASCULAR DISEASE, 2011
Rizwan Hamid, Eric Austin, Bethany Womack, Lora Hedges, James E. Loyd, Joy D. Cogan   +5 more
openaire   +1 more source