Results 31 to 40 of about 189 (150)

Mental Disorders and Quality of Life in Patients With Pulmonary Arterial Hypertension Treated With Sotatercept

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT Sotatercept has recently expanded treatment options for pulmonary arterial hypertension (PAH), but its mental health and quality‐of‐life impact is not well characterized. We assessed psychiatric diagnoses and patient‐reported outcomes in PAH patients treated with sotatercept within the clinical trial program.
Jan Fuge, Karen M. Olsson, Kira Remmert, Britta Stapel, Jan C. Kamp, Da‐Hee Park, Marius M. Hoeper, Lotta Winter, Kai G. Kahl   +8 more
wiley   +1 more source

Inhalation Cancer Risk Associated with Exposure to Complex Polycyclic Aromatic Hydrocarbon Mixtures in an Electronic Waste and Urban Area in South China

, 2016
Atmospheric particulate matter samples were collected from May 2010 to April 2011 in a rural e-waste area and in Guangzhou, South China, to estimate the lifetime inhalation cancer risk from exposure to parent polycyclic aromatic hydrocarbons (PAHs), high
Takeshi Ohura (743354), Leah Gonzales (2049022), Staci L. Massey Simonich (1332480), Shejun Chen (2049019), Mi Tian (728601), Bixian Mai (712956), Xiaobo Zheng (154892), Jing Wang (1228470)   +7 more
core   +1 more source

Generation of 5 hiPSC lines from pediatric patients with Heritable pulmonary arterial hypertension (HPAH) caused by heterozygous mutations in the TBX4 gene

Stem Cell Research
Heritable pulmonary arterial hypertension (HPAH) and underlying pulmonary vascular disease (PVD) are often caused by TBX4 mutations-either loss- or gain-of-function-which are a leading cause of childhood-onset PAH. The clinically heterogeneous TBX4 syndrome can include skeletal anomalies (e.g., small patella syndrome) and developmental lung disease ...
Valeria Fernandez Vallone, Kristin Fischer, Judit Küchler, Franziska Diekmann, Georg Hansmann, Harald Stachelscheid   +5 more
openaire   +2 more sources

Balancing Risk and Hope: Insights Into Pregnancy Outcomes in Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
This cohort study demonstrates that vasoreactive status identifies a low‐risk subgroup in PAH pregnancies, characterised by zero major or minor adverse events, unlike the significant complications seen in non‐vasoreactive patients. These distinct outcomes underscore the need for risk‐stratified, personalized management for pregnant women with PAH ...
Teresa Segura de la Cal, Carmen Pérez‐Olivares, Raquel Luna‐López, Irene Martín de Miguel, Alejandro Cruz‐Utrilla, Olga Villar, Fernando Sarnago, Pedro Muñoz, Marina Santiago Sánchez, María Jesús López Gude, Maite Velázquez, Laura Forcén, Juan F. Delgado, Fernando Arribas Ynsaurriaga, Pilar Escribano‐Subias   +14 more
wiley   +1 more source

A Multicenter, Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial of Oral Anticoagulation in Systemic Sclerosis‐Related Pulmonary Arterial Hypertension—Results From the SPHInX Study

Pulmonary Circulation, Volume 16, Issue 2, June 2026.
ABSTRACT The SPHInX study is the first‐ever randomized controlled trial (RCT) seeking to inform an area of equipoise regarding the efficacy of oral anticoagulation as adjunct therapy in systemic sclerosis‐related pulmonary arterial hypertension (SSc‐PAH).
Mandana Nikpour, Alicia Calderone, Susanna M. Proudman, Dylan Hansen, Eli Gabbay, Nathan Dwyer, Gregory Keir, Vivek Thakkar, Peter K. K. Wong, Anne Keogh, Andrew Burns, David Prior, Harshal Nandurkar, David S. Celermajer, Joanne Sahhar, Rachelle Buchbinder, Wendy Stevens   +16 more
wiley   +1 more source

Cellular Signalling Networks in High Altitude Pulmonary Hypertension: From Canonical Pathways to Emerging Targets

Cell Proliferation, Volume 59, Issue 4, April 2026.
This review elucidates the intricate cellular signalling networks involved in high‐altitude pulmonary hypertension (HAPH), integrating canonical pathways like HIF, MAPK and BMP with emerging targets such as Wnt/β‐catenin, Notch, Hippo‐YAP and IL‐6. It highlights potential therapeutic strategies targeting these pathways to mitigate vascular remodelling ...
Sheng Ding, Ju Chen, Zhaoyang Li, Yang Yu, Weijie Wang, Yan Liao, Jin Yang, Dianxiang Lu, Yujiang Fan   +8 more
wiley   +1 more source

Human exposure to parent and halogenated polycyclic aromatic hydrocarbons via food consumption in Shenzhen, China

, 2013
Human exposure to polycyclic aromatic hydrocarbons (PAHs) and halogenated PAHs (HPAHs) via food consumption is still not clear in south China so far. The goals of this work are to assess human exposure to parent and halogenated PAHs via food ingestion ...
Ni, Hong-Gang, Zeng, Hui, Ding, Chao
core   +1 more source

Temporal trends of polycyclic aromatic hydrocarbons (PAHs) in a dated sediment core of a high atitude mountain lake: Chungara Lake-Northern Chile (18° S) [PDF]

, 2014
In this study levels, fuxes and temporal trend of PAHs are reported in a sediment core from Chungará Lake (18° S) in Northern Chile. The sediments were obtained by Kayac corer and freeze dried.
Gomez V., Urrutia R., Perra G., Pozo K., Barra R.   +4 more
core   +1 more source

Bioaccumulation of hydrocarbon compounds in the muscle of three aquatic birds in Um Alnaaj Marsh, Iraq

, 2022
The current study was conducted to determine the concentrations and origins of total petroleum hydrocarbon TPHs and polycyclic aromatic hydrocarbons PAHs in three bird species of Anas platyrhynchos, A. crecca and A.
Idan, Firas Sabeeh, Jazza, Salih Hassan
core   +1 more source

Exploring the Application Value of Magnetocardiography in Detecting Pulmonary Hypertension: A Noninvasive and Visual Approach

Clinical Cardiology, Volume 49, Issue 3, March 2026.
MCG may serve as a noninvasive, visualized tool for detecting PH. ABSTRACT Background Exploring accurate and noninvasive methods for detecting pulmonary hypertension (PH) has always been a focal point of research. Owing to its exceptional spatiotemporal resolution, magnetocardiography (MCG) has demonstrated potential value in cardiovascular diseases ...
Yuankun Qi, Jiaqi Liang, Yu Zhang, Jianzhi Yang, Fuzhi Cao, Xu Zhang, Haijun Li, Xiaopei Cui, Hongyu Zhang, Min Xiang   +9 more
wiley   +1 more source