Results 31 to 40 of about 54,472 (289)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An innovative technological infrastructure for managing SARS-CoV-2 data across different cohorts in compliance with General Data Protection Regulation

Digital Health
Background The ORCHESTRA project, funded by the European Commission, aims to create a pan-European cohort built on existing and new large-scale population cohorts to help rapidly advance the knowledge related to the prevention of the SARS-CoV-2 infection
Chiara Dellacasa, Maurizio Ortali, Elisa Rossi, Hammam Abu Attieh, Thomas Osmo, Miroslav Puskaric, Eugenia Rinaldi, Fabian Prasser, Caroline Stellmach, Salvatore Cataudella, Bhaskar Agarwal, Juan Mata Naranjo, Gabriella Scipione   +12 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Evaluation of the performance of a hydraulic barrier by the Null space Monte Carlo method

Acque Sotterranee, 2019
A gasoline leak caused the contamination of a shallow alluvial aquifer in an urbanized area in Northern Italy. A rapid intervention was conceived to stop the spreading of contamination: a hydraulic barrier has been placed downstream of the source to ...
Giovanni Formentin, Jacopo Terrenghi, Mariangela Vitiello, Alberto Francioli   +3 more
doaj   +1 more source

Adjustment of Coatings Morphology and Particle Distribution of Layered Silicates by Freeze‐Drying for Improved Gas Barriers

Advanced Engineering Materials, EarlyView.
Freeze‐drying of layered silicate is the key to get coatings with superior gas barrier. Freeze‐drying of layered silicates modified with dodecylamine (DDA) is a highly effective technique for the preparation of barrier pigments that significantly mitigate the permeation of oxygen, water vapor, and hydrogen through polymer films containing these ...
Joshua Lommes, Moritz Bätcher, Andrea Deißenberger, Volkmar Stenzel, Andreas Hartwig   +4 more
wiley   +1 more source

Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases

Nature Communications, 2021
TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. Using computational electrophysiology simulations, the authors identify the main ion-conductive state ...
Andrei Y. Kostritskii, Jan-Philipp Machtens   +1 more
doaj   +1 more source

Interpreting the meaning of changes in hippocampal volume associated with vestibular loss

Frontiers in Integrative Neuroscience, 2023
Many studies have documented cognitive deficits, especially spatial cognitive deficits, in patients with some form of vestibular loss. Almost 20 years ago, hippocampal (HPC) atrophy was reported to be correlated with spatial memory deficits in such ...
Paul F. Smith, Paul F. Smith
doaj   +1 more source

The HPC Certification Forum: Toward a Globally Acknowledged HPC Certification [PDF]

Computing in Science & Engineering, 2020
The goal of the HPC Certification Forum is to categorize, define, and examine competencies expected from proficient HPC practitioners. The community-led forum is working toward establishing a globally acknowledged HPC certification process, a process that engages with HPC centres to identify gaps in users’ knowledge, and with users to identify the ...
Kunkel, Julian, Filinger, Weronika, Meesters, Christian, Gerbes, Anja   +3 more
openaire   +2 more sources

Enabling Digital Continuity in Virtual Manufacturing for Eco‐Efficiency Assessment of Lightweight Structures by Means of a Domain‐Specific Structural Mechanics Language: Requirements, Idea and Proof of Concept

Advanced Engineering Materials, EarlyView.
This article presents a solver‐agnostic domain‐specific language (DSL) for computational structural mechanics that strengthens interoperability in virtual product development. Using a hierarchical data model, the DSL enables seamless exchange between diverse simulation tools and numerical methods.
Martin Rädel, Andreas Schuster, Felix Schoenitz, Jean Lefèvre   +3 more
wiley   +1 more source

Estimation of Irregular Wave Runup on Intermediate and Reflective Beaches Using a Phase-Resolving Numerical Model

Journal of Marine Science and Engineering, 2020
Accurate wave runup estimations are of great interest for coastal risk assessment and engineering design. Phase-resolving depth-integrated numerical models offer a promising alternative to commonly used empirical formulae at relatively low computational ...
Jonas Pinault, Denis Morichon, Volker Roeber   +2 more
doaj   +1 more source