Results 81 to 90 of about 53,196 (246)

ControlPULP: A RISC-V On-Chip Parallel Power Controller for Many-Core HPC Processors with FPGA-Based Hardware-In-The-Loop Power and Thermal Emulation [PDF]

, 2023
Alessandro Ottaviano, Robert Balas, Giovanni Bambini, Antonio Del Vecchio, Maicol Ciani, Davide Rossi, Luca Benini, Andrea Bartolini   +7 more
openalex   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Multi-ensemble machine learning framework for omics data integration: A case study using breast cancer samples

Informatics in Medicine Unlocked
Integration of voluminous omics data aids to unravel biological complexities associated with different disease phenotypes. Machine learning (ML) approaches provide insightful techniques for systematic multi-omics data integration. In this study, survival
Kunal Tembhare, Tina Sharma, Sunitha M. Kasibhatla, Archana Achalere, Rajendra Joshi   +4 more
doaj   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Transient Antiskyrmion‐Mediated Topological Transitions in Isotropic Magnets

Advanced Science, EarlyView.
A transient antiskyrmion‐mediated pathway that drives repeated stripe‐to‐skyrmion transitions is revealed, producing a net increase in topological charge in isotropic Dzyaloshinskii–Moriya interaction films. Experiments and simulations identify the antiskyrmion as a metastable excitation, enabling stochastic bitstream generation for probabilistic ...
Bingqian Dai, Tianyi Wang, Albert Lee, Shijie Xu, Zhongjian Bian, Xinyue Zhu, Puyang Huang, Aadi Chaturvedi, Yaochen Li, Yang Cheng, Qingyuan Shu, Haoran He, Hanshen Huang, Lixuan Tai, Kin Wong, Jinbo Yang, Anjan Soumyanarayanan, Zhaochu Luo, Kang L. Wang   +18 more
wiley   +1 more source

A new generation of HPC developers using quantum Monte Carlo (QMC) methods is growing

, 2021
Sara Pittonet, Julie Abergas-Arteza, Jacopo Mariani   +2 more
openalex   +1 more source

HPC framework for in-silico trials on 3D virtual human cardiac population to assess drug-induced arrhythmic risk [PDF]

, 2021
Jazmín Aguado‐Sierra, Constantine Butakoff, Renee C. Brigham, Apollo K. Baron, Guillaume Houzeaux, María José Guerra Palmero, Francesc Carreras Costa, David Filgueiras‐Rama, Paul A. Iaizzo, Tinen L. Iles, Mariano Vázquez   +10 more
openalex   +1 more source

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

PM100: A Job Power Consumption Dataset of a Large-Scale HPC System

, 2023
Francesco Antici, Mohsen Seyedkazemi Ardebili, Andrea Bartolini, Zeynep Kiziltan   +3 more
openalex   +2 more sources