Results 161 to 170 of about 607,274 (305)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Tiamin (B1-vitamin) származék napraforgómag extraktumában való akkumulációjának vizsgálata HPLC módszerrel

, 2019
A vitaminok az anyagcsere-folyamatok számos fázisában fontos szerepet töltenek be, ezért szervezetünk számára alapvető a megfelelő vitamin ellátottság. Ennek elérésében a változatos táplálkozás kulcsfontosságú.
Szabó, Szabolcs
core  

From Conventional Methods to Innovation: Caffeine and Chlorogenic Acid Extraction and Quantification in the Rise of Smart and Green Techniques-A Systematic Review. [PDF]

Molecules
Awwad SH, Nasereddin LM, Al-Tamimi O, Daraosheh AQ, Elrashidi A, Abu Al-Shayeb L, Shannag M, Mohammad BA, Issa R, Abu-Samak MS.   +9 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Studies of hexahelicene bonded phases for the HPLC resolution of enantiomers [PDF]

The thesis presents a review of the literature on the HPLC resolution of enantiomers using chiral stationary phases and discusses the mechanisms of separation and the utility of these phases.
Del Alamo, Aurora
core  

Comparative evaluation of ELISA, PPIA, and HPLC/MS for microcystin quantification in seven lakes of western Michigan. [PDF]

Front Microbiol
Cheng C, Tang X, Cai Y, Deng D, Xie L, Rediske RR.   +5 more
europepmc   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

White Analytical Perspective on Lamivudine Determination: HPLC-PDA and HPLC-ELSD Method Development, Validation, and Multimetric Evaluation. [PDF]

ACS Omega
Sezgin B, Arli G, Aydın E, Soyseven M.
europepmc   +1 more source

MetalCenter‐Dependent Selectivity Divergence in MN4 Single‐Atom Catalysts for Aerobic HMF Oxidation

Advanced Science, EarlyView.
Two single‐atom catalysts with M‐N4 configurations (FeN4 and CoN4) were developed for selective HMF oxidation. FeN4 achieves 93.9% selectivity toward FFCA via superoxide anions (O2•−), while CoN4 preferentially produces FDCA through hydroxyl radicals (•OH). DFT calculations reveal that distinct adsorption energies and charge redistribution at the metal
Haoyu Wang, Zhilong Ye, Weihao Wang, Zhi Hu, Qing Tian, Jie Gao, Lianbing Zhang   +6 more
wiley   +1 more source

Fast, easy and green method for the first quantification of niacinamide in serums and creams by digital image analysis using iron (III) chloride. [PDF]

Mikrochim Acta
Lambarri A, Ostra M, Bordagaray A, Garcia-Arrona R, Vidal M.   +4 more
europepmc   +1 more source